Hungry for life: How the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction
| Autor: | Rafael de Cabo, Joy W. Chang, Robin K. Minor |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Aging
medicine.medical_specialty Calorie Hunger media_common.quotation_subject Longevity Calorie restriction Neuropeptide Biology Models Biological Biochemistry Article chemistry.chemical_compound Endocrinology Arcuate nucleus Internal medicine medicine Animals Humans Neuropeptide Y Neurotransmitter Molecular Biology Caloric Restriction media_common Arcuate Nucleus of Hypothalamus Appetite Neuropeptide Y receptor chemistry Hypothalamus |
| Zdroj: | Molecular and Cellular Endocrinology. 299:79-88 |
| ISSN: | 0303-7207 |
| Popis: | Laboratory studies consistently demonstrate extended lifespan in animals on calorie restriction (CR), where total caloric intake is reduced by 10–40% but adequate nutrition is otherwise maintained. CR has been further shown to delay the onset and severity of chronic diseases associated with aging such as cancer, and to extend the functional health span of important functions including cognition. Less understood are the underlying mechanisms through which CR might act to induce such alterations. One theory postulates that CR’s beneficial effects are intimately tied to the neuroendocrine response to low energy availability, of which the arcuate nucleus in the hypothalamus plays a pivotal role. Neuropeptide Y (NPY), a neurotransmitter in the front line of the arcuate response to low energy availability, is the primary hunger signal affected by CR and therefore may be a critical mechanism for lifespan extension. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect