Gender differences in drug toxicity
| Autor: | Tamara J Nicolson, Howard R. Mellor, Ruth A. Roberts |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
Drug Male Sex Characteristics Drug-Related Side Effects and Adverse Reactions business.industry media_common.quotation_subject Toxicology Bioinformatics Body weight Hormones Efficacy Pharmaceutical Preparations Toxicity Medicine Humans Hormone metabolism Female business Adverse effect Carrier Proteins Drug toxicity media_common Sex characteristics |
| Zdroj: | Trends in pharmacological sciences. 31(3) |
| ISSN: | 1873-3735 |
| Popis: | Clinical data suggest that gender dimorphic profiles are emerging in terms of both drug efficacy and adverse drug reactions (ADRs). With an increasing emphasis on individualised therapies and the need to prevent drug attrition there is a compelling need to understand the molecular basis for gender dimorphic profiles in ADRs and the consequences. Classes of agents exhibiting gender-based variation in pharmaceutical efficacy and toxicity include anaesthetics, HIV-1 therapies and antiarrhythmic drugs. Body weight differences are often cited as a reason for differences in drug pharmacokinetics and subsequent toxicity. However, some studies accounted for these factors and still found significance suggesting that dosage versus body weight does not explain the outcome. Here, we present an overview of current understanding of gender-specific drug toxicity and present rational molecular explanations for these adverse events. There is mounting evidence in support of hormonal effects underpinning the majority of the ADR differences observed between the sexes. |
| Databáze: | OpenAIRE |
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