Grading of macular perfusion in retinal vein occlusion using en-face swept-source optical coherence tomography angiography: a retrospective observational case series

Autor: Mohsen A Abou Shousha, Mohamed M. A. Lolah, Amr Saad Bessa, Tarek Abdelrazek Hafez, Magdy Moussa, Hazem El Hennawi, Mahmoud Leila
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Visual acuity
Time Factors
genetic structures
Posterior pole
Visual Acuity
chemistry.chemical_compound
0302 clinical medicine
lcsh:Ophthalmology
Occlusion
Macula Lutea
Fluorescein Angiography
Aged
80 and over
General Medicine
Middle Aged
Female
medicine.symptom
Perfusion
Tomography
Optical Coherence
Research Article
Adult
medicine.medical_specialty
Retinal Vein
Fundus Oculi
Ischemia
SS-OCTA in retinal vein occlusion
03 medical and health sciences
Young Adult
Ophthalmology
Grading of macular perfusion
Retinal Vein Occlusion
medicine
Humans
SS-OCTA
Aged
Retrospective Studies
business.industry
Microcirculation
Retinal Vessels
Retinal
medicine.disease
eye diseases
Capillaries
chemistry
lcsh:RE1-994
030221 ophthalmology & optometry
Branch retinal vein occlusion
business
030217 neurology & neurosurgery
Zdroj: BMC Ophthalmology, Vol 19, Iss 1, Pp 1-13 (2019)
BMC Ophthalmology
ISSN: 1471-2415
Popis: Background To evaluate the efficacy of swept –source optical coherence tomography angiography (SS-OCTA) in grading macular perfusion in retinal vein occlusion. Methods Retrospective observational case series including patients with different types of retinal vein occlusion (RVO). SS-OCTA utilizes OCTARA algorithm to examine the retinal vascular plexuses for the presence of morphological signs of ischemia according to a predetermined grading scheme. The findings were compared with fundus fluorescein angiography (FFA), and swept-source optical coherence tomography (SS-OCT) features. Bivariate correlation, coefficient of determination, and crosstabs procedures were used to calculate inter-variable linear correlation, relative contribution of the tested variables, and multivariate association, respectively. Results The study included 144 eyes of 138 patients. The most common type of RVO was branch retinal vein occlusion (BRVO) (53%). The superficial capillary plexus (SCP) and the deep capillary plexus (DCP) did not correlate with each other in all parameters tested. Increased central macular thickness (CMT) and disrupted retinal outer layers (DROL) were associated with increased severity of ischemia in DCP. Disorganized retinal inner layers (DRIL) correlated significantly with the presence of perifoveal capillary ischemia in the SCP and the DCP. Macular ischemia on FFA correlated with ischemia in the SCP layer only. Increased CMT, DROL and DRIL on SS-OCT, and SCP and DCP ischemia on SS-OCTA contributed significantly to diminished best-corrected visual acuity (BCVA). Conclusion SS-OCTA is more precise in defining the extent and location of maximum ischemic insult following RVO compared to FFA, hence represents a more efficient grader for ischemic damage in the posterior pole. Increased CMT, DRIL, and DROL on SS-OCT, and SCP and DCP ischemia on SS-OCTA are significant predictors of poor visual outcome.
Databáze: OpenAIRE
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