T cell subsets and immunoglobulin G levels are associated with the infection status of systemic lupus erythematosus patients

Autor: Ying Guo, Haiyan Ji, Li-Fen Wu, Hou Hou, Wenwen Sun, Wei Wei, Fenghua Chen, Lu Gong, Xinru Wang, Xing Lv
Rok vydání: 2018
Předmět:
Male
Physiology
Polymerase Chain Reaction
Biochemistry
Immunoglobulin G
0302 clinical medicine
Risk Factors
T-Lymphocyte Subsets
immune system diseases
Lupus Erythematosus
Systemic
030212 general & internal medicine
General Pharmacology
Toxicology and Pharmaceutics
Young adult
skin and connective tissue diseases
lcsh:QH301-705.5
Research Articles
lcsh:R5-920
biology
General Neuroscience
Complement C4
Complement C3
General Medicine
Middle Aged
Flow Cytometry
medicine.anatomical_structure
Antibodies
Antinuclear
Female
Serum Globulins
Antibody
lcsh:Medicine (General)
Infection
Adult
Adolescent
Globulin
T cell
Immunology
Biophysics
Enzyme-Linked Immunosorbent Assay
Ocean Engineering
Infections
Statistics
Nonparametric
Young Adult
03 medical and health sciences
Systemic lupus erythematosus
Nephelometry and Turbidimetry
medicine
Humans
Aged
030203 arthritis & rheumatology
Lupus erythematosus
business.industry
Case-control study
Cell Biology
medicine.disease
lcsh:Biology (General)
biology.protein
business
T cell subsets
CD8
Zdroj: Brazilian Journal of Medical and Biological Research, Volume: 51, Issue: 2, Article number: e4547, Published: 11 DEC 2017
Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research v.51 n.2 2018
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 51, Iss 2 (2017)
ISSN: 1414-431X
0100-879X
Popis: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disorder that affects nearly all organs and tissues. As knowledge about the mechanism of SLE has increased, some immunosuppressive agents have become routinely used in clinical care, and infections have become one of the direct causes of mortality in SLE patients. To identify the risk factors indicative of infection in SLE patients, a case control study of our hospital's medical records between 2011 and 2013 was performed. We reviewed the records of 117 SLE patients with infection and 61 SLE patients without infection. Changes in the levels of T cell subsets, immunoglobulin G (IgG), complement C3, complement C4, globulin, and anti-double-stranded DNA (anti-ds-DNA) were detected. CD4+ and CD4+/CD8+ T cell levels were significantly lower and CD8+ T cell levels were significantly greater in SLE patients with infection than in SLE patients without infection. Additionally, the concentrations of IgG in SLE patients with infection were significantly lower than those in SLE patients without infection. However, complement C3, complement C4, globulin, and anti-ds-DNA levels were not significantly different in SLE patients with and without infection. Therefore, clinical testing for T cell subsets and IgG is potentially useful for identifying the presence of infection in SLE patients and for distinguishing a lupus flare from an acute infection.
Databáze: OpenAIRE
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