T cell subsets and immunoglobulin G levels are associated with the infection status of systemic lupus erythematosus patients
Autor: | Ying Guo, Haiyan Ji, Li-Fen Wu, Hou Hou, Wenwen Sun, Wei Wei, Fenghua Chen, Lu Gong, Xinru Wang, Xing Lv |
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Rok vydání: | 2018 |
Předmět: |
Male
Physiology Polymerase Chain Reaction Biochemistry Immunoglobulin G 0302 clinical medicine Risk Factors T-Lymphocyte Subsets immune system diseases Lupus Erythematosus Systemic 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Young adult skin and connective tissue diseases lcsh:QH301-705.5 Research Articles lcsh:R5-920 biology General Neuroscience Complement C4 Complement C3 General Medicine Middle Aged Flow Cytometry medicine.anatomical_structure Antibodies Antinuclear Female Serum Globulins Antibody lcsh:Medicine (General) Infection Adult Adolescent Globulin T cell Immunology Biophysics Enzyme-Linked Immunosorbent Assay Ocean Engineering Infections Statistics Nonparametric Young Adult 03 medical and health sciences Systemic lupus erythematosus Nephelometry and Turbidimetry medicine Humans Aged 030203 arthritis & rheumatology Lupus erythematosus business.industry Case-control study Cell Biology medicine.disease lcsh:Biology (General) biology.protein business T cell subsets CD8 |
Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 51, Issue: 2, Article number: e4547, Published: 11 DEC 2017 Brazilian Journal of Medical and Biological Research Brazilian Journal of Medical and Biological Research v.51 n.2 2018 Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Vol 51, Iss 2 (2017) |
ISSN: | 1414-431X 0100-879X |
Popis: | Systemic lupus erythematosus (SLE) is a chronic, autoimmune disorder that affects nearly all organs and tissues. As knowledge about the mechanism of SLE has increased, some immunosuppressive agents have become routinely used in clinical care, and infections have become one of the direct causes of mortality in SLE patients. To identify the risk factors indicative of infection in SLE patients, a case control study of our hospital's medical records between 2011 and 2013 was performed. We reviewed the records of 117 SLE patients with infection and 61 SLE patients without infection. Changes in the levels of T cell subsets, immunoglobulin G (IgG), complement C3, complement C4, globulin, and anti-double-stranded DNA (anti-ds-DNA) were detected. CD4+ and CD4+/CD8+ T cell levels were significantly lower and CD8+ T cell levels were significantly greater in SLE patients with infection than in SLE patients without infection. Additionally, the concentrations of IgG in SLE patients with infection were significantly lower than those in SLE patients without infection. However, complement C3, complement C4, globulin, and anti-ds-DNA levels were not significantly different in SLE patients with and without infection. Therefore, clinical testing for T cell subsets and IgG is potentially useful for identifying the presence of infection in SLE patients and for distinguishing a lupus flare from an acute infection. |
Databáze: | OpenAIRE |
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