Role of the FKBP5 polymorphism rs1360780, age, sex, and type of surgery in weight loss after bariatric surgery: a follow-up study
| Autor: | Assumpta Caixàs, Elionora Peña, Araceli Rosa, Concepción Arenas, Narcís Cardoner, Mercedes Rigla, Sara Crivillés |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Sleeve gastrectomy medicine.medical_treatment Gastric Bypass Bariatric Surgery 030209 endocrinology & metabolism Tacrolimus Binding Proteins 03 medical and health sciences Sex Factors 0302 clinical medicine Gastrectomy Weight loss Weight Loss Genotype medicine Humans Allele Alleles Aged Retrospective Studies business.industry Age Factors Middle Aged medicine.disease Obesity Obesity Morbid Surgery Treatment Outcome Spain Cohort Female Laparoscopy 030211 gastroenterology & hepatology FKBP5 medicine.symptom business Body mass index Follow-Up Studies |
| Zdroj: | Surgery for Obesity and Related Diseases. 16:581-589 |
| ISSN: | 1550-7289 |
| DOI: | 10.1016/j.soard.2019.12.002 |
| Popis: | Background Emerging evidence suggests that the FK506 binding protein 51 (FKBP5/FKBP51), encoded by the FKBP5 gene, influences weight and metabolic regulation. The T allele of a functional polymorphism in FKBP5 (rs1360780), has been associated with the expression of FKBP51 and weight loss after bariatric surgery. Objective To examine the role of the FKBP5 rs1360780 polymorphism in relation to age, sex, and type of surgery in weight loss after bariatric surgery in patients with severe obesity. Setting University Hospital in Spain Methods A cohort of 151 obese patients submitted to Roux-en-Y gastric bypass (62.3%) and sleeve gastrectomy (37.7%) were followed-up during 24-months (t24m; loss to follow-up: 0%). During the postoperative period body mass index (BMI) and percentage of excess and total weight loss were evaluated. Results The BMI analysis showed an effect of the interaction FKBP5 genotype by sex (P = .0004) and a tendency to the interaction genotype by surgery (P = .048), so that men carrying the T allele had higher BMI at t24m than those without the T allele, and T-allele carriers that underwent sleeve gastrectomy had higher BMI at t24m than the noncarriers. Additionally, we found an interaction between FKBP5 and age for the percentage of excess weight loss and BMI (P = .0005 and P = 1.5e−7, respectively), whereby individuals >48 years with the T allele displayed significant differences for the analyzed variables at t24m compared with the homozygotes for the alternate C allele showing lower weight loss. Conclusion FKBP5 rs1360780 genotype has specific effects on weight loss outcomes after bariatric surgery depending on sex, age, and type of surgery, suggesting worse results in older males carrying the T allele who have undergone sleeve gastrectomy. |
| Databáze: | OpenAIRE |
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