Evolution of fibrosis during HCV recurrence after liver transplantation--influence of IL-28B SNP and response to peg-IFN and ribavirin treatment
| Autor: | Anders Sönnerborg, Ola Weiland, Malin Ackefors, Jessica Nyström, Annika Wernerson, Henrik Gjertsen |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Adolescent Genotype medicine.medical_treatment Liver transplantation Gastroenterology Antiviral Agents Polymorphism Single Nucleotide Severity of Illness Index chemistry.chemical_compound Young Adult Fibrosis Recurrence Virology Internal medicine Ribavirin Medicine SNP Humans Genetic Predisposition to Disease Child Aged Hepatology medicine.diagnostic_test business.industry Interleukins Hcv recurrence Fibrosis stage Hepatitis C Chronic Middle Aged medicine.disease Liver Transplantation Infectious Diseases chemistry Liver biopsy Immunology Female Interferons business |
| Zdroj: | Journal of viral hepatitis. 20(11) |
| ISSN: | 1365-2893 |
| Popis: | Summary The IL-28 gene is associated with sustained viral response (SVR) after treatment with peg-IFN and ribavirin in liver transplant recipients with chronic hepatitis C genotype 1 infection. We analysed the importance of recipient and donor IL-28B genotype for response to treatment and fibrosis progression in 54 liver transplant recipients. Fibrosis stage (F) was defined as mild when F ≤ 2 and severe when F ≥ 3 in a liver biopsy or according to liver elasticity analysis. We found a significantly lower prevalence of IL-28B SNP CC in the recipients (22%) than in the donors (67%), P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text