DC-SIGN as a Receptor for HTLV-1 Binding, Entry and Infection
| Autor: | Karan Kampani, Zafar K. Khan, Jaya Ahuja, Brian Wigdahl, Suman Datta, Pooja Jain |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
viruses T cell T-cell leukemia virus diseases Biology medicine.disease Virology Pathogenesis DC-SIGN Infectious Diseases medicine.anatomical_structure immune system diseases hemic and lymphatic diseases Immunology Tropical spastic paraparesis biology.protein medicine Gene silencing Antibody lcsh:RC581-607 Receptor |
| Zdroj: | Retrovirology, Vol 2, Iss Suppl 1, p P39 (2005) |
| ISSN: | 1742-4690 |
| Popis: | Human T cell leukemia virus type 1 (HTLV-1) has been identified as the etiologic agent of adult T cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Numerous studies have demonstrated that patients diagnosed with HAM/TSP exhibit rapid activation and maturation of dendritic cells (DCs) while ATL is associated with their maturation defect. In addition to T cells, HTLV-1 is known to infect DCs. HTLV1 infection of DCs could alter general DC function or the specific processing and/or presentation of HTLV-1-specific peptides, potentially playing a major role in the course of HTLV-1-associated disease. In this regard, we have demonstrated that an important antigen receptor on DCs, DC-SIGN serves as a receptor for HTLV-1 binding using a quantum dot-based fluorescent binding assay. We have also demonstrated that gene silencing of DC-SIGN inhibits the infection of DC in a DC/T cell co-infection system. Furthermore, expression of DC-SIGN in B cells enhances viral binding, integration, and infection. These investigations, which consider the involvement of DC surface molecules in HTLV-1 pathogenesis, are the first explorations of the intricate mechanisms that underlie the interactions between DCs and HTLV-1. from 2005 International Meeting of The Institute of Human Virology Baltimore, USA, 29 August – 2 September 2005 |
| Databáze: | OpenAIRE |
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