Acute auditory and vestibular symptoms associated with heat and transdermal lidocaine
| Autor: | Nima L. Shemirani, David R. Friedland, Darryl Tang |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Ataxia Hot Temperature Lidocaine Administration Cutaneous Heating pad Pharmacokinetics Vertigo medicine Humans Anesthetics Local Auditory Diseases Central Transdermal Aged Pain Measurement biology business.industry biology.organism_classification Surgery Anesthesiology and Pain Medicine Vestibular Diseases Anesthesia Toxicity Neurology (clinical) medicine.symptom business Tinnitus medicine.drug |
| Zdroj: | The Clinical journal of pain. 26(1) |
| ISSN: | 1536-5409 |
| Popis: | Objectives To describe a case of systemic lidocaine toxicity from the simultaneous use of transdermal patches and a heating pad. Methods Case report and discussion. Results The focus of this case report are the interesting neuro-otologic signs of central lidocaine toxicity that occurred after a patient fell asleep on a heating pad with his Lidoderm patches in place. Hearing improvement, tinnitus reduction, and severe dizziness and ataxia were present for approximately 48 hours before spontaneous resolution. Based upon his symptoms we estimate an 11-fold increase in plasma concentrations of lidocaine. Discussion Transdermal delivery of medication affords ease of application, ability to provide continuous pharmacological therapy, and ability to supply medication to the affected site. Due to the superficial application of these medications, external environmental factors may influence the pharmacokinetics of drug delivery. This case highlights the complications that can arise from the combination of heating pads and transdermal pain therapies. |
| Databáze: | OpenAIRE |
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