Trabectedin-related rhabdomyolysis: an uncommon but fatal toxicity

Autor: Aikaterini Stoyianni, Nikolaos Kapodistrias, Eleutherios Kampletsas, George Pentheroudakis, Nicholas Pavlidis
Jazyk: angličtina
Rok vydání: 2011
Předmět:
0301 basic medicine
Leiomyosarcoma
Cancer Research
Uterine Neoplasms/*drug therapy/enzymology/pathology
Dioxoles
Comorbidity
Antineoplastic Agents
Alkylating/administration & dosage/*adverse effects

Dioxoles/administration & dosage/*adverse effects
Rhabdomyolysis
Tetrahydroisoquinolines/administration & dosage/*adverse effects
03 medical and health sciences
0302 clinical medicine
Creatine Kinase/*blood
Fatal Outcome
Tetrahydroisoquinolines
Humans
Drug Interactions
Renal Insufficiency
Biological Markers/blood
Renal Insufficiency/etiology
Antineoplastic Agents
Alkylating

Creatine Kinase
Rhabdomyolysis/*chemically induced/complications/enzymology
Aged
Leiomyosarcoma/*drug therapy/enzymology/secondary
General Medicine
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Uterine Neoplasms
Female
Biomarkers
Trabectedin
Popis: Rhabdomyolysis is defined as the dissolution of striped muscle characterized by the leakage of intracellular muscle components into the circulation, which can ultimately lead to renal failure with a possible fatal outcome. Trabectedin is a potential cause of rhabdomyolysis. Herein, we describe a case of rhabdomyolysis in a female patient with recurrent metastatic leiomyosarcoma of the uterus and who had full recovery, and we review the already published cases in order to identify a common pattern of emergence.
Databáze: OpenAIRE