Subjects with mild and moderate asthma respond to segmental allergen challenge with similar, reproducible, allergen-specific inflammation
| Autor: | Peter L. Wisnewski, Wendy C. Moore, Jeffrey D. Hasday, Barbara White, Eugene R. Bleecker, Susan S. Meltzer |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Spirometry
Adult Male Allergy Immunology Provocation test Vital Capacity medicine.disease_cause FEV1/FVC ratio Allergen immune system diseases Immunopathology Forced Expiratory Volume Immunology and Allergy Medicine Humans Asthma Inflammation medicine.diagnostic_test business.industry Respiratory disease Reproducibility of Results respiratory system Allergens medicine.disease respiratory tract diseases Female business Bronchoalveolar Lavage Fluid |
| Zdroj: | The Journal of allergy and clinical immunology. 108(6) |
| ISSN: | 0091-6749 |
| Popis: | Background: The relationship between severity of asthma and bronchial inflammation is poorly understood. Objective: We examined acute and subacute inflammatory responses to allergen in subjects with mild and moderate persistent asthma to evaluate whether different cellular and mediator responses to endobronchial allergen challenge are associated with differences in disease severity. Methods: Segmental allergen challenge was performed in 8 subjects with mild and 10 subjects with moderate allergic asthma to compare baseline airways inflammation and allergen-induced inflammatory responses 24 hours later. This evaluation was repeated after 6 weeks in 9 subjects to investigate the reproducibility of these inflammatory responses. Results: Subjects with mild and moderate asthma had similar decreases in FEV 1 in response to segmental allergen challenge (9.1% ± 4.2% vs 15.1% ± 4.6%, P = .35). There was no difference in inflammatory cell counts or cytokine concentrations in the groups with mild and moderate asthma at baseline or after saline or allergen challenge. Repeat segmental allergen challenge 6 weeks later showed that these cellular and cytokine responses were reproducible. Conclusion: Segmental allergen challenge in subjects with mild and moderate asthma produces similar allergen-specific physiologic and inflammatory responses that are reproducible 6 weeks later. In this model of allergic asthma, acute responses to allergen do not appear to be related to disease severity. (J Allergy Clin Immunol 2001;108:908-14.) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect