The association between antibodies to neurotropic pathogens and bipolar disorder : A study in the Dutch Bipolar (DB) Cohort and meta-analysis
| Autor: | Marieke J. H. Begemann, Hans C. van Mierlo, Manja Litjens, René S. Kahn, Lot de Witte, Marco P. Boks, Arjen L. Sutterland, Roel A. Ophoff, G. Snijders |
|---|---|
| Přispěvatelé: | Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Graduate School, Adult Psychiatry |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Bipolar Disorder Gastroenterology Cohort Studies 0302 clinical medicine Risk Factors Seroepidemiologic Studies Psychology Viral Netherlands biology Middle Aged Serious Mental Illness 3. Good health Titer Psychiatry and Mental health Mental Health Protozoan Cohort Public Health and Health Services Female Toxoplasma Toxoplasmosis Human Cohort study Adult medicine.medical_specialty Clinical Sciences Antibodies 03 medical and health sciences Cellular and Molecular Neuroscience Internal medicine medicine Journal Article Humans Seroprevalence Bipolar disorder Risk factor Biological Psychiatry Herpesvirus 1 business.industry Herpesvirus 2 Prevention Case-control study Toxoplasma gondii Herpes Simplex medicine.disease biology.organism_classification Brain Disorders 030227 psychiatry Logistic Models Emerging Infectious Diseases Immunoglobulin G Case-Control Studies business 030217 neurology & neurosurgery |
| Zdroj: | Translational psychiatry, vol 9, iss 1 Translational psychiatry, 9(1):311. Nature Publishing Group Translational Psychiatry, 9(1). Nature Publishing Group |
| ISSN: | 2158-3188 |
| Popis: | Exposure to neurotropic pathogens has been hypothesized to be a risk factor for the development of bipolar disorder (BD). However, evidence so far is inconsistent. We, therefore, analyzed the seroprevalence and titer levels of IgG antibodies against several herpesviruses and Toxoplasma gondii (T. gondii) in plasma of 760 patients with a bipolar disorder, 144 first-degree matched relatives and 132 controls of the Dutch Bipolar (DB) Cohort using ELISA. In addition, we performed a literature-based meta-analysis on the seroprevalence of IgG antibodies against these pathogens (n = 14). Our results in the DB Cohort and subsequent meta-analysis (n = 2364 BD patients, n = 5101 controls) show no association between exposure to herpesviruses and bipolar disorder (HSV-1 [adjusted OR 0.842, 95% CI 0.567–1.230], HSV-2 [adjusted OR 0.877, 95% CI 0.437–1.761], CMV [adjusted OR 0.884 95% CI 0.603–1.295], EBV [adjusted OR 0.968 95% CI 0.658–1.423]). In the DB Cohort, we did not find an association between bipolar disorder and T. gondii titer or seroprevalence either [adjusted OR 1.018, 95% CI 0.672–1.542]. The overall OR was not significant for T. gondii [OR: 1.4, 95% CI 0.95–1.90, p = 0.09), but subgroup analyses in age groups below 40 years showed a significantly increased seroprevalence of T. gondii IgGs in BD [OR: 1.8 (95% CI 1.10–2.89, p = 0.021]. Our meta-analysis indicates that T. gondii exposure may be a risk factor for BD in certain subpopulations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|