On-Site and Quantitative Detection of Trace Methamphetamine in Urine/Serum Samples with a Surface-Enhanced Raman Scattering-Active Microcavity and Rapid Pretreatment Device
| Autor: | Zhang-Na Qin, Fang-Yuan Han, Jiming Hu, Yu-Qi Feng, Aiguo Shen, Wei Fang, Biao Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Analyte
Monolithic HPLC column Trace Amounts Surface Properties Metal Nanoparticles Spectrum Analysis Raman 010402 general chemistry 01 natural sciences Methamphetamine Analytical Chemistry symbols.namesake chemistry.chemical_compound Humans Crystal violet Microscale chemistry Chemistry business.industry 010401 analytical chemistry 0104 chemical sciences symbols Optoelectronics Gold business Raman spectroscopy Quantitative analysis (chemistry) Raman scattering |
| Zdroj: | Analytical Chemistry. 92:13539-13549 |
| ISSN: | 1520-6882 0003-2700 |
| DOI: | 10.1021/acs.analchem.0c03041 |
| Popis: | Here, it reports a high-throughput detection method for reliably quantitative analysis of illegal drugs in complex biological samples by means of a surface-enhanced Raman scattering (SERS) active microcavity and rapid pretreatment device. Based on the well-made hemispherical microcavities that regularly distributed on a glass array, the quality-controllable microcavity device is fabricated by the compact self-assembly of core-shell nanopeanuts (CSNPs) onto the inside surface. Both the CSNPs with a quantifiable internal standard signal of crystal violet acetate anchored inside their gap and the well-made microcavity referred to the physical amplification of the microscale groove surface will do well in trace analysis, which will allow us to realize the accurately quantitative SERS analysis of targeted analytes spread on the bottom area of the microcavity array. As an example, 0.8 nM malachite green and 160 ppb methamphetamine (MATM) have been successively detected in a wide range as standard, while even 0.01 ppm MATM mixed in the urine/serum samples has been efficiently tested by the microcavity device equipped with a rapid pretreatment device (manual monolithic column syringe needle). All of the above suggest that the SERS-active microcavity equipped with a rapid pretreatment device has potential in the on-site quick test of trace amounts of illegal drugs in bodily fluid samples or other field analysis of food sanitation, environmental safety, and public health. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|