Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression?

Autor: Mo-Xuan, Wang, Shu-Yue, Gao, Fan, Yang, Run-Jia, Fan, Qin-Na, Yang, Tian-Lan, Zhang, Nian-Song, Qian, Guang-Hai, Dai
Rok vydání: 2022
Předmět:
Zdroj: World Journal of Clinical Oncology. 13:729-737
ISSN: 2218-4333
DOI: 10.5306/wjco.v13.i9.729
Popis: Immunotherapy has shown great promise in treating various types of malignant tumors. However, some patients with gastrointestinal cancer have been known to experience rapid disease progression after treatment, a situation referred to as hyperprogressive disease (HPD). This minireview focuses on the definitions and potential mechanisms of HPD, natural disease progression in gastrointestinal malignancies, and tumor immunological microenvironment.
Databáze: OpenAIRE