Outcome of elderly patients with classical Hodgkin’s lymphoma
| Autor: | Marie Lukasova, Katerina Klaskova, A. Sykorova, K Chroust, Vít Procházka, Jana Markova, J. Koren, Heidi Mocikova, L Buresova, David Belada, Lubica Gaherova, Pavla Stepankova |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Anthracycline medicine.medical_treatment Kaplan-Meier Estimate macromolecular substances Multimodal Imaging Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Antineoplastic Combined Chemotherapy Protocols Outcome Assessment Health Care medicine Humans Public Health Surveillance Registries Progression-free survival Aged Czech Republic Aged 80 and over Chemotherapy business.industry Complete remission Disease Management Hematology Middle Aged Prognosis medicine.disease Hodgkin's lymphoma Hodgkin Disease Classical Hodgkin's Lymphoma Lymphoma Radiation therapy Treatment Outcome Oncology 030220 oncology & carcinogenesis Female business 030215 immunology |
| Zdroj: | Leukemia Research. 90:106311 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2020.106311 |
| Popis: | The optimal management of elderly patients (pts) with Hodgkin's lymphoma is not yet defined. The aims of the present study were: 1) to evaluate clinical and laboratory characteristics of elderly pts; 2) to indentify risk factors for unfavorable outcome.The outcome of 182 pts ≥ 60 years (y) was retrospectively analyzed (median age, 67y). Mixed cellularity histology was diagnosed in 49.5 %, advanced stage of disease was in 68.7 % pts, CIRS3 in 35.7 %, ECOG PS ≥ 2 in 22.9 % (60-69y) of pts. Chemotherapy (CMT) alone was used in 69.2 % and combination of CMT and radiotherapy in 26.9 % of pts. Anthracycline-based CMT received 83.5 % of pts. The median follow-up was 4.5y.The overall response/complete remission rate was 85.6/70.7 %. The median progression free survival (PFS) and overall survival (OS) were 10y and 11.3y, respectively. Estimated 5-y PFS and 5-y OS were 65.7 % (in contrast to 98.2 % in pts60y; p0.001) and 70.5 % (99.4 % in pts60y; p0.001). Overall 70 (38.5 %) elderly pts died. The independent risk factors for a shorter OS included CIRS3, lymphopenia8 % and anthracycline-free CMT, for a shorter PFS anthracycline-free CMT and lymphopenia8 %.CIRS3, lymphopenia8 % and anthracycline-free chemotherapy appear to be significant for unfavorable outcome. |
| Databáze: | OpenAIRE |
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