Incidence, clinical findings and management of intraoperative floppy iris syndrome associated with tamsulosin
| Autor: | Kaan Ünlü, Uğur Keklikçi, Yusuf Celik, Kenan Isen, Mine Karahan |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Tamsulosin medicine.medical_specialty Epinephrine Administration Topical medicine.medical_treatment Intraoperative floppy iris syndrome Cataract Extraction Odds Ratio medicine Humans Prospective Studies Intraoperative Complications Prospective cohort study Adrenergic alpha-Antagonists Aged Aged 80 and over Sulfonamides business.industry Incidence (epidemiology) General Medicine Odds ratio Middle Aged Cataract surgery medicine.disease Confidence interval Surgery Ophthalmology Iris Diseases Relative risk Female business Adrenergic alpha-Agonists medicine.drug |
| Zdroj: | Acta Ophthalmologica. 87:306-309 |
| ISSN: | 1755-3768 1755-375X |
| DOI: | 10.1111/j.1755-3768.2008.01246.x |
| Popis: | Purpose: To determine the risk ratios and incidence of intraoperative floppy iris syndrome (IFIS) during cataract surgery in patients using tamsulosin, and to assess management strategies for IFIS. Methods: We performed a non-randomized, observational, prospective study, in which 594 eyes of 579 patients undergoing cataract surgery were enrolled. Surgeons were masked to the patients’ drug history. Usage or non-usage of tamsulosin, duration of tamsulosin use, presence or absence of IFIS, management of IFIS and intraoperative complications were recorded in the patients’ theatre notes. Results: Twelve of 15 (80%) IFIS patients were taking systemic tamsulosin. Twelve of 23 (52%) patients using tamsulosin showed features of IFIS. The odds ratios (ORs) and relative risk (RR) ratios show strong positive correlations between tamsulosin use and IFIS. The ORs and RR ratios and the 95% confidence intervals (CIs) are as follows: OR 206.5 (95% CI 50.9–836.5); RR 99.3 (95% CI 30.0–327.8). There were no statistically significant differences between patients with or without IFIS, who were using tamsulosin, in terms of age or duration of tamsulosin use (p > 0.05). Seven eyes (46.6%) with IFIS were successfully managed with epinephrine. Eight eyes (53.4%) with IFIS needed iris hooks. Conclusions: Patients using tamsulosin appear to be at high risk of IFIS during cataract surgery. The occurrence of IFIS may not be affected by duration of tamsulosin use or age. Epinephrine may be effective in approximately 50% of eyes with IFIS. The iris hook procedure represents an effective management strategy in IFIS. |
| Databáze: | OpenAIRE |
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