Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine

Autor: Vivian Song, Simon D. Tran, Jose G. Munguia-Lopez, David T. Wu, Zhiyue Zhu, Ye Won Cho, Xiaolu Ma
Rok vydání: 2021
Předmět:
Scaffold
Regenerative endodontics
Pharmaceutical Science
Organic chemistry
regenerative medicine
Biocompatible Materials
02 engineering and technology
Review
Regenerative medicine
Analytical Chemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
QD241-441
Tissue engineering
stomatognathic system
bone regeneration
Drug Discovery
Hyaluronic acid
periodontal regeneration
Humans
sinus augmentation
Physical and Theoretical Chemistry
Bone regeneration
polymers
salivary gland regeneration
Decellularization
Tissue Scaffolds
Chemistry
Regeneration (biology)
technology
industry
and agriculture
030206 dentistry
pulp regeneration
polymeric scaffolds
021001 nanoscience & nanotechnology
3. Good health
stomatognathic diseases
Chemistry (miscellaneous)
tissue engineering
whole tooth regeneration
Molecular Medicine
0210 nano-technology
Biomedical engineering
Zdroj: Molecules
Molecules, Vol 26, Iss 7043, p 7043 (2021)
ISSN: 1420-3049
Popis: Dental, oral, and craniofacial (DOC) regenerative medicine aims to repair or regenerate DOC tissues including teeth, dental pulp, periodontal tissues, salivary gland, temporomandibular joint (TMJ), hard (bone, cartilage), and soft (muscle, nerve, skin) tissues of the craniofacial complex. Polymeric materials have a broad range of applications in biomedical engineering and regenerative medicine functioning as tissue engineering scaffolds, carriers for cell-based therapies, and biomedical devices for delivery of drugs and biologics. The focus of this review is to discuss the properties and clinical indications of polymeric scaffold materials and extracellular matrix technologies for DOC regenerative medicine. More specifically, this review outlines the key properties, advantages and drawbacks of natural polymers including alginate, cellulose, chitosan, silk, collagen, gelatin, fibrin, laminin, decellularized extracellular matrix, and hyaluronic acid, as well as synthetic polymers including polylactic acid (PLA), polyglycolic acid (PGA), polycaprolactone (PCL), poly (ethylene glycol) (PEG), and Zwitterionic polymers. This review highlights key clinical applications of polymeric scaffolding materials to repair and/or regenerate various DOC tissues. Particularly, polymeric materials used in clinical procedures are discussed including alveolar ridge preservation, vertical and horizontal ridge augmentation, maxillary sinus augmentation, TMJ reconstruction, periodontal regeneration, periodontal/peri-implant plastic surgery, regenerative endodontics. In addition, polymeric scaffolds application in whole tooth and salivary gland regeneration are discussed.
Databáze: OpenAIRE
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