Antibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysis
| Autor: | Soheila Aghlmandi, Jan A Roth, Sarah Ursula Sutter, Andreas F. Widmer, Hans-Helge Seifert, Kathrin Bausch, Christian Appenzeller-Herzog, Hannah Ewald, Linda Maria Stamm |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Bacteriuria Antibiotic resistance 030232 urology & nephrology MEDLINE lcsh:Medicine Medicine (miscellaneous) Antimicrobial stewardship Guideline law.invention 03 medical and health sciences Transitional cell carcinoma Postoperative Complications 0302 clinical medicine Meta-Analysis as Topic Randomized controlled trial Antibiotics law Protocol Urothelium cell carcinoma medicine Humans 030212 general & internal medicine Antibiotic prophylaxis Intensive care medicine business.industry lcsh:R Recommendation Antibiotic Prophylaxis medicine.disease Endourological surgery Anti-Bacterial Agents Regimen Urinary Bladder Neoplasms Meta-analysis Urinary Tract Infections business Systematic Reviews as Topic |
| Zdroj: | Systematic Reviews Systematic Reviews, Vol 9, Iss 1, Pp 1-6 (2020) |
| ISSN: | 2046-4053 |
| DOI: | 10.1186/s13643-020-01353-2 |
| Popis: | Background The necessity of antibiotic prophylaxis for postoperative urinary tract infections (UTIs) after transurethral resection of bladder tumours is controversial. This potentially leads to the overuse of antibiotic prophylaxis and rising antimicrobial resistance rates. The objective of this systematic review and meta-analysis is to compare the impact of different antimicrobial prophylaxis schemes versus placebo on the prevention of postoperative UTI and asymptomatic bacteriuria. Methods We designed and registered a study protocol for a systematic review and meta-analysis of randomized controlled trials and non-randomized (e.g. cohort, case-control) studies examining any form of antibiotic prophylaxis in patients with transurethral resection of bladder tumours. Literature searches will be conducted in several electronic databases (from inception onwards), including MEDLINE (Ovid), EMBASE (Ovid), and the Cochrane Central Register of Controlled Trials (CENTRAL). Grey literature will be identified through searching conference abstracts. The primary outcome will be postoperative urinary tract infections. The secondary outcome will be asymptomatic bacteriuria. Two reviewers will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or bias) will be appraised using appropriate tools (e.g. Risk of Bias 2.0 tool and Newcastle-Ottawa Scale). If feasible, we will conduct random-effects meta-analysis of outcome data. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g. study design, publication year, the setting of the study, and antibiotics regimen). We will also search, identify, and discuss potential risk factors for urinary tract infections following transurethral resection of bladder tumours. This may serve as basis for a scoping review. Discussion In times of rising antimicrobial resistance rates, sound evidence on the necessity of antibiotic prophylaxis is essential for implementation into guideline recommendations and for decision-making in clinical practice. Systematic review registration PROSPERO, CRD42019131733 |
| Databáze: | OpenAIRE |
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