Is Karnofsky Performance Status Correlate with Better Overall Survival in Palliative Conformal Whole Brain Radiotherapy? Our Experience
| Autor: | Maria Grazia Ruo Redda, Alessia Reali, Roberta Verna, Andrea Girardi, Simona Allis, Lavinia Bianco |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty Pathology Multivariate analysis Karnofsky performance status Prognostic factors Breast cancer Internal medicine medicine Overall survival lcsh:R5-920 medicine.diagnostic_test Karnofsky Performance Status business.industry Health Policy Medical record Public Health Environmental and Occupational Health Magnetic resonance imaging Brain metastases Whole brain radiotherapy medicine.disease Primary tumor Cohort Original Article lcsh:Medicine (General) business |
| Zdroj: | Indian Journal of Palliative Care Indian Journal of Palliative Care, Vol 21, Iss 3, Pp 311-316 (2015) |
| Popis: | Aim: Brain metastases (BMs) are a common event in the progression of many human cancers. The aim of this study was to evaluate the potential prognostic factors for the clinical identification of a subgroup of patients that could benefit from whole brain conformal radiotherapy (WBRT). Materials and Methods: From January 2010 to February 2014, 80 patients with a diagnosis of BMs underwent WBRT at our Radiation Oncology Department, San Luigi Hospital, Italy. Among them, 36 medical records were retrospective reviewed. Gender, age, Karnofsky performance status (KPS), number of BMs on computed tomography and/or magnetic resonance images, presence or absence of perilesional edema, presence or absence of necrosis pattern, and histology of primary tumor were analyzed. Univariate and multivariate analyses were performed. Results: In our cohort of patients, significant prognostic factors for 20 months overall survival was KPS> 70, while a statistical trend (P = 0.098) was registered regarding primary breast. Conclusion: WBRT can be still considered a standard and effective treatment in patients with BMs. High KPS and breast cancer primary tumor seem to be useful parameters for characterize a subgroup of patients with more favorable prognosis. |
| Databáze: | OpenAIRE |
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