Age at diagnosis in women with non-metastatic breast cancer: Is it related to prognosis?
Autor: | Magda El-Mongy, Eman M. Gouda, Dalia Bilal, Amal S. Ibrahim, Salem E. Salem, Nelly Alieldin, Omnia M. Abo-Elazm |
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Jazyk: | angličtina |
Předmět: |
Oncology
Adult medicine.medical_specialty Disease free survival Multivariate analysis Axillary lymph nodes Disease-free survival medicine.medical_treatment Lobular carcinoma Age at diagnosis Breast Neoplasms Kaplan-Meier Estimate Prognostic factors lcsh:RC254-282 Young Adult Breast cancer Internal medicine Materials Chemistry medicine Humans Age of Onset Aged Proportional Hazards Models Aged 80 and over Medicine(all) business.industry Young age Hazard ratio Carcinoma Ductal Breast Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Prognosis Radiation therapy medicine.anatomical_structure Treatment Outcome Multivariate Analysis Female business |
Zdroj: | Journal of the Egyptian National Cancer Institute, Vol 26, Iss 1, Pp 23-30 (2014) |
ISSN: | 1110-0362 |
DOI: | 10.1016/j.jnci.2013.08.005 |
Popis: | Objective Primary objective was to verify whether breast cancer patients aged less than 40 years at diagnosis have poorer prognosis than older patients. Secondary to assess prognostic factors influencing disease free survival. Methods 941 women were diagnosed with non-metastatic breast cancer at NCI, Cairo in 2003. Epidemiologic, clinico-pathological characteristics, treatment modalities and disease free survival were compared among the two age groups. Prognostic factors were evaluated for association with disease-free survival. Results One hundred-eighty-one patients (19.2%) were younger than 40 years and 760 (80.8%) were older. Older women presented with higher rates of comorbidities and younger women presented with more hormone non-responsive tumors. Young women presented with larger tumors pT4 = 13.8% compared to 8.6% in older women, yet not significant. Young women were treated with more conservative surgery, more adjuvant chemotherapy and radiotherapy while older women with more radical mastectomies and more hormonal treatment. Recurrence rates were significantly higher among young women 44.2% compared to 34.5% in older women. Five year disease free survival in young women was 38.9% ± 4.6% compared to 48.6% ± 2.5% with adjusted hazard ratio of 1.22 95% CI (0.91–1.64), p = 0.19. Multivariate analyses identified positive axillary lymph nodes (pN2-pN3), larger tumor size (pT3-pT4), hypertension, lobular carcinoma type and lack of adjuvant systemic treatment as independent factors associated with poor DFS. Conclusion Young women were not found to have poorer prognosis, yet they presented with more ER negative tumors. Most of women presented with advanced stage and young women had higher recurrence rates. |
Databáze: | OpenAIRE |
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