Insulin-like growth factor (IGF)-binding protein-4 inhibits colony formation of colorectal cancer cells by IGF-independent mechanisms
| Autor: | Daniela Diehl, Andreas Hoeflich, Eckhard Wolf, Harald Lahm |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
medicine.medical_specialty Cell division Colorectal cancer medicine.medical_treatment Endogeny Biology Insulin-like growth factor Somatomedins Internal medicine Cell Line Tumor medicine Humans Neoplasm Invasiveness RNA Messenger Cell growth Binding protein Cell migration medicine.disease Endocrinology Oncology Insulin-Like Growth Factor Binding Protein 4 Cell culture Cancer research Colorectal Neoplasms Cell Division |
| Zdroj: | Cancer research. 64(5) |
| ISSN: | 0008-5472 |
| Popis: | Effects of insulin-like growth factor-binding protein-4 (IGFBP-4) on proliferation, colony formation, and cell migration were assessed in IGF-sensitive and -insensitive colorectal cancer cell lines. In IGF-insensitive Isreco-1 cells, overexpression of IGFBP-4 reduced colony formation but not cell proliferation and migration, whereas exogenous IGF-II had no effect. In IGF-dependent LS1034 cells, IGFBP-4 inhibited all parameters of growth tested, whereas IGF-II partially restored reduced proliferation and cell migration only. In Isreco-2 cells, which lack endogenous IGF expression but are IGF sensitive, colony formation was also reduced by IGFBP-4. Therefore, specific parameters of malignant progression of colon carcinoma cells are distinctly affected by IGF-dependent and IGF-independent effects of IGFBP-4. |
| Databáze: | OpenAIRE |
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