Assessment of inflammation in noninfectious chronic maxillary sinusitis
| Autor: | Lawrence B. Schwartz, Bernard Guerrier, Pascal Demoly, François B. Michel, I. Enander, Michel Mondain, Nadine Lequeuxc, Jean Bousquet, Alison M. Campbell, Louis Crampette |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Hypersensitivity Immediate Male Pathology medicine.medical_specialty Rhinitis Allergic Perennial Adolescent Immunology Tryptase Diagnosis Differential Nonallergic rhinitis otorhinolaryngologic diseases medicine Humans Immunology and Allergy Eosinophilia Prospective Studies Sinusitis Aged Rhinitis Eosinophil cationic protein biology business.industry Chronic sinusitis Endoscopy Maxillary Sinus Middle Aged Eosinophil Maxillary Sinusitis Nasal Lavage Fluid medicine.disease Immunohistochemistry medicine.anatomical_structure Chronic Disease biology.protein Major basic protein Female medicine.symptom business |
| Zdroj: | Journal of Allergy and Clinical Immunology. 94:95-108 |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/0091-6749(94)90076-0 |
| Popis: | Background and aim: Pathologic examination of the sinus mucosa and titration of inflammatory mediators in the sinus fluid were carried out to characterize inflammation in chronic sinusitis and determine whether patients with chronic allergic rhinitis (CAR) and sinusitis differ from patients with chronic nonallergic rhinitis (CNAR) and sinusitis. Methods: Nine control subjects (patients requiring ear, nose, and throat surgery not related to sinusitis), 12 patients with CAR and sinusitis, and 13 patients with CNAR and sinusitis were investigated. Eosinophil cationic protein, tryptase, myeloperoxidase, histamine, and prostaglandin D 2 were measured in the sinus lavage fluids, and cells were enumerated. The cellular infiltrate was studied by immunohistochemistry with monoclonal antibodies against eosinophil cationic protein (eosinophils), tryptase (mast cells), neutrophil elastase (neutrophils), CD3 (lymphocytes), CD68 (macrophages), and proliferating cell nuclear antigens. Results: Neutrophils were not increased in sinusitis. In comparison with control subjects, patients with CAR and CNAR with sinusitis showed significant increases in eosinophils and macrophages in biopsy specimens and in eosinophil cationic protein in sinus lavage fluids. In comparison with patients with CNAR, patients with CAR had an increased number of intraepithelial mast cells and lymphocytes. Conclusions: These findings suggest that patients with CNAR and sinusitis can be distinguished from patients with CAR and sinusitis, which resembles nonallergic rhinitis with eosinophilia syndrome. (J ALLERGY CLIN IMMUNOL 1994;94:95-108.) |
| Databáze: | OpenAIRE |
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