Moringa oleifera extract enhances sexual performance in stressed rats
| Autor: | Sitthichai Iamsaard, Opass Sritragool, Pichet Somsapt, Supaporn Muchimapura, Jintanaporn Wattanathorn, Thawatchai Prabsattroo, Wipawee Thukhummee |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Monoamine Oxidase Inhibitors Antioxidant medicine.medical_treatment Biology medicine.disease_cause Antioxidants General Biochemistry Genetics and Molecular Biology Moringa Sexual Behavior Animal chemistry.chemical_compound Stress Physiological Dopamine Corticosterone Internal medicine Testis medicine Animals Aphrodisiac Amino Acids Rats Wistar General Pharmacology Toxicology and Pharmaceutics Moringa oleifera General Veterinary Plant Extracts Aphrodisiacs Articles General Medicine Phosphodiesterase 5 Inhibitors Rats Plant Leaves Sexual Dysfunction Physiological Monoamine neurotransmitter Endocrinology chemistry cGMP-specific phosphodiesterase type 5 Oxidative stress Phytotherapy medicine.drug |
| Zdroj: | Journal of Zhejiang University-SCIENCE B. 16:179-190 |
| ISSN: | 1862-1783 1673-1581 |
| DOI: | 10.1631/jzus.b1400197 |
| Popis: | Aphrodisiacs are required to improve male sexual function under stressful conditions. Due to the effects of oxidative stress and dopamine on male sexual function, we hypothesized that Moringa oleifera leaves might improve male sexual dysfunction induced by stress. Therefore, the effects on various factors playing important roles in male sexual behavior, such as antioxidant effects, the suppression of monoamine and phosphodiesterase type 5 (PDE-5) activities, serum testosterone and corticosterone levels, and histomorphological changes in the testes, of a hydroethanolic extract of M. oleifera leaves were investigated. Various doses of extract including 10, 50, and 250 mg/kg body weight (BW) were given orally to male Wistar rats before exposure to 12 h-immobilization stress for 7 d. The results demonstrated that the extract showed both antioxidant and monoamine oxidase type B (MAO-B) suppression activities. At 7 d of treatment, the low dose of extract improved sexual performance in stress-exposed rats by decreasing intromission latency and increasing intromission frequency. It also suppressed PDE-5 activity, decreased serum corticosterone level, but increased serum testosterone, numbers of interstitial cells of Leydig and spermatozoa. The increased numbers of interstitial cells of Leydig and spermatozoa might have been due to the antioxidant effect of the extract. The increased sexual performance during the intromission phase might have been due to the suppression of MAO-B and PDE-5 activities and increased testosterone. Therefore, M. oleifera is a potential aphrodisiac, but further research concerning the precise underlying mechanisms is still needed. |
| Databáze: | OpenAIRE |
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