Alteration of the Fatty Acid Metabolism in the Rat Kidney Caused by the Injection of Serum from Patients with Collapsing Glomerulopathy
| Autor: | María Elena Soto, Linaloe Manzano Pech, Verónica Guarner-Lans, Maria del Carmen Avila-Casado, Israel Pérez-Torres, Elizabeth Soria-Castro |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
systolic blood pressure 030232 urology & nephrology Medicine (miscellaneous) Renal function 030204 cardiovascular system & hematology fatty acids General Biochemistry Genetics and Molecular Biology Article Nephropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine lcsh:QH301-705.5 chemistry.chemical_classification Kidney Proteinuria Fatty acid metabolism collapsing glomerulopathy business.industry Cholesterol Fatty acid medicine.disease medicine.anatomical_structure Endocrinology lcsh:Biology (General) chemistry Arachidonic acid medicine.symptom proteinuria business |
| Zdroj: | Biomedicines Volume 8 Issue 10 Biomedicines, Vol 8, Iss 388, p 388 (2020) |
| ISSN: | 2227-9059 |
| Popis: | Patients with collapsing glomerulopathy (CG) have marked proteinuria that rapidly progresses to chronic renal failure. In this study, we investigated if the nephropathy produced in a rat model by the injection of serum from CG patients induced alterations in fatty acid (FA) metabolism. Twenty-four female Sprague-Dawley rats were divided into four groups of six rats each: Group I, control rats (C) Group II, rats that received injections of 1 mL of 0.9% NaCl saline solution (SS) Group III, rats injected with 25 mg/mL of serum from healthy subjects (HS) and Group IV, rats injected with 25 mg/mL of serum from CG patients. In all groups, the systolic blood pressure (SBP), proteinuria, creatinine clearance (CC), cholesterol and total FA composition in the kidney and serum were evaluated. The administration of serum from CG patients to rats induced glomerular collapse, proteinuria, reduced CC and elevated SBP (p &le 0.01) in comparison with the C, SS and HS rats. The FA composition of the serum of rats that received the CG serum showed an increase in palmitic acid (PA) and a decrease in arachidonic acid (AA) when compared to serum from HS (p &le 0.02). In rats receiving the CG serum, there was also a decrease in the AA in the kidney but there was an increase in the PA in the serum and kidney (p &le 0.01). These results suggest that the administration of serum from CG patients to rats induces alterations in FA metabolism including changes in PA and in AA, which are precursors for the biosynthesis of the prostaglandins that are involved in the elevation of SBP and in renal injury. These changes may contribute to collapsing glomerulopathy disease. |
| Databáze: | OpenAIRE |
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