Influence of arotinolol hydrochloride on heart rate spectrum in hypertensive subjects
| Autor: | Michiko Momohara, Hiroyuki Masaki, Yasuhiko Harasawa, A. Takeshita, Tsutomu Imaizumi, Seiki Harada, Shin-ichi Ando |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Sympathetic Nervous System Physiology RR interval Adrenergic beta-Antagonists Blood Pressure Arotinolol hydrochloride Propanolamines Heart Rate Parasympathetic Nervous System Internal medicine Heart rate medicine Humans Spectral analysis business.industry Systemic blood pressure Middle Aged Atenolol Endocrinology Blood pressure Hypertension Female Cardiology and Cardiovascular Medicine business Arotinolol medicine.drug |
| Zdroj: | Japanese circulation journal. 58(5) |
| ISSN: | 0047-1828 |
| Popis: | Influence of arotinolol hydrochloride and atenolol on the balance between the sympathetic and parasympathetic nervous systems was evaluated in 8 hypertensive subjects by spectral analysis of heart rate (HR) and systemic blood pressure (BP). Before and after administration of either arotinolol (n = 7) or atenolol (n = 7) for 2 weeks, BP was continuously and non-invasively monitored by a finger-cuff manometry (Finapres). A time series of instantaneous HR was constructed from the BP signal. A time series of mean BP was also constructed. Spectral analysis was performed by the use of an autoregressive algorithm on these time series (approximately 180 sec). Each spectrum was subdivided into low-(0.05-0.15 Hz, LF) and high-frequency (0.15-0.4 Hz, HF) components, and each component was divided by the sum of the two for normalization. As a measure of the balance between the sympathetic and parasympathetic nervous systems, the ratio of LF to HF (LF/HF) was evaluated. Arotinolol increased fractional HF in the HR spectrum from 0.45 +/- 0.12 to 0.73 +/- 0.08 (p < 0.01) and decreased fractional LF from 0.55 +/- 0.12 to 0.27 +/- 0.08 (p < 0.01); consequently, it decreased LF/HF from 1.4 +/- 0.5 to 0.4 +/- 0.2 (p < 0.01). Atenolol had similar effects on these parameters. Neither of these beta-adrenergic blockades produced a discernible decrease in LF/HF in the BP spectrum. In conclusion, these beta-adrenergic blockades decreased LF/HF in the HR spectrum in hypertensive subjects, which suggests that they improved the balance between the sympathetic and parasympathetic nervous systems. |
| Databáze: | OpenAIRE |
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