Preparation and in-vitro evaluation of β-CD/HA nanocomposite as a potential carrier for hydrophobic drugs
| Autor: | Esmaeil Salimi, Mohammad Jafar Molaei |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Drug
Morphology (linguistics) media_common.quotation_subject Biomedical Engineering Crystal structure 01 natural sciences Dexamethasone Nanocomposites Biomaterials 03 medical and health sciences 0302 clinical medicine 0103 physical sciences Fourier transform infrared spectroscopy media_common chemistry.chemical_classification Drug Carriers Nanocomposite 010304 chemical physics Cyclodextrin Chemistry beta-Cyclodextrins Hydrogen-Ion Concentration Drug Liberation Durapatite Chemical bond Drug delivery 030221 ophthalmology & optometry Hydrophobic and Hydrophilic Interactions Nuclear chemistry |
| Zdroj: | Journal of Biomaterials Applications. 36:246-251 |
| ISSN: | 1530-8022 0885-3282 |
| Popis: | This study aimed to provide a new drug delivery system for hydrophobic compounds. Dexamethasone (DEX) was employed as a hydrophobic model drug, which incorporated into the network of hydroxyapatite (HA)/Cyclodextrin (β-CD) nanocomposite. Phase analysis, chemical bonding, morphology, and drug release was evaluated using XRD, FTIR, FESEM, and UV-vis spectroscopy, respectively. XRD patterns showed the formation of the crystalline structure and FTIR analysis showed the chemical bonding between organic and inorganic phases. FESEM images accompanied by EDX analysis confirmed the presence of HA nano-flakes. Release of DEX loaded β-CD/HA was measured to be around 4.6% and 18.7% in pH5.3 and pH 7.4, respectively. In conclusion, the prepared system could be a potential pH sensitive carrier for sustainable release of water-insoluble drugs. |
| Databáze: | OpenAIRE |
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