Emergence of abstract sound representations in the ascending auditory system
| Autor: | Leila Khouri, Mor Harpaz, Maciej M. Jankowski, Israel Nelken |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Sound (medical instrument) Inferior colliculus Auditory Cortex Auditory Pathways Computer science General Neuroscience Geniculate Bodies Medial geniculate body Auditory cortex Adaptation Physiological Inferior Colliculi 03 medical and health sciences Tone (musical instrument) 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Acoustic Stimulation Tone Frequency medicine Auditory system Humans Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Progress in neurobiology. 202 |
| ISSN: | 1873-5118 |
| Popis: | Auditory processing begins by decomposing sounds into their frequency components, raising the question of where the representation of sounds as wholes emerges in the auditory system. To address this question, we used stimulus-specific adaptation (SSA), the reduction in the responses of a neuron to a common sound (standard) which does not generalize to another, rare sound (deviant). SSA to tone frequency has been demonstrated in multiple stations of the auditory pathway, including the inferior colliculus (IC), medial geniculate body (MGB) and auditory cortex. We designed wideband stimuli (tone clouds) that have identical frequency components but are nevertheless distinct. Tone clouds evoked early and substantial SSA in primary auditory cortex (A1) but only late and minor SSA in IC and MGB. These results imply that while in IC and MGB sounds are largely represented in terms of their frequency components, in A1 they are represented as abstract entities. |
| Databáze: | OpenAIRE |
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