Non-tuberculous mycobacteria (NTM) in Zambia: prevalence, clinical, radiological and microbiological characteristics
| Autor: | Mathias Tembo, Eveline Klinkenberg, Pascalina Chanda-Kapata, Nathan Kapata, Martin P. Grobusch, Patrick Katemangwe, Veronica Sunkutu, Lutinala Mulenga, Peter Mwaba |
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| Přispěvatelé: | Other departments, Graduate School, Global Health, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Infectious diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Tuberculosis HIV Positivity Adolescent Cross-sectional study Epidemiology Mycobacterium Infections Nontuberculous Zambia Young Adult Medical microbiology Risk Factors Internal medicine HIV Seropositivity Non-tuberculous mycobacteria Diagnosis medicine Prevalence Humans Survey Lung Aged Emerging Public health biology business.industry Coinfection Sputum Nontuberculous Mycobacteria Mycobacterium tuberculosis Middle Aged biology.organism_classification medicine.disease bacterial infections and mycoses Radiography Infectious Diseases Cross-Sectional Studies Cough Immunology Nontuberculous mycobacteria Female medicine.symptom business Research Article |
| Zdroj: | BMC Infectious Diseases BMC infectious diseases, 15(1). BioMed Central |
| ISSN: | 1471-2334 |
| Popis: | Background Non-tuberculous mycobacteria (NTM) infection is an emerging health problem. We present here the Zambia-specific national level data of prevalence, symptomatic, radiological and microbiological characteristics of NTM, using results from a national Tuberculosis (TB) prevalence survey. Methods This was a cross-sectional study of the prevalence of NTM among adults aged 15 years and above, who were participants in a national TB prevalence survey. Participants who had either an abnormal chest x-ray or were symptomatic were considered presumptive TB cases and submitted sputum for smear and culture analysis. HIV testing was performed on an opt-out basis. Symptomatic NTM prevalence was estimated from individual level analysis. Results Of the 6,123 individuals with presumptive TB, 923 (15.1 %) were found to have NTM, 13 (0.2 %) were MTB/NTM co-infected and 338 (5.5 %) were contaminated (indeterminate). The prevalence of symptomatic NTM was found to be 1,477/100,000 [95 % CI 1010–1943]. Smear positivity, history of cough or chest pain and HIV positivity were risk factors for NTM. Conclusion This first study to estimate the national prevalence of NTM in Zambia indicates that the burden is high. The NTM occurrence in Zambia constitutes both a public health and ethical issue requiring action from health managers. |
| Databáze: | OpenAIRE |
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