POLYMER SUPPORTED SYNTHESIS OF DEOXYOLIGONUCLEOTIDES USING INSITU PREPARED DEOXYNUCLEOSIDE 2-CYANOETHYL PHOSPHORAMIDITES

Autor:	Michael Taagaard, John Nielsen, Jacques H. van Boom, J.E. Marugg, Bjarne H. Dahl, Otto Dahl
Předmět:	Deoxyribonucleoside In situ chemistry.chemical_compound chemistry Organic chemistry Tetrazole DNA Polymer supported
Zdroj:	University of Copenhagen
Popis:	2-Cyanoethyl bis(diisopropylamino) phosphorodiamidite (1) is a stable and easily obtainable compound1 which, when activated with 0.5 eq. tetrazole, gives solutions of deoxyribonucleoside 2-cyano-ethyl phosphoramidites (2) useful for the synthesis of deoxyoligo-nucleotides. 2 Our results applying these in-situ prepared phosphoramidites for polymer-supported syntheses of a variety of deoxyoligonucleotides (DNA fragments) will be presented.
Databáze:	OpenAIRE
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