Role of the Hsp90-immunophilin heterocomplex in cancer disease
| Autor: | Nadia R Zgajnar, Gisela Ileana Mazaira, Alejandra G. Erlejman, Mario D. Galigniana, Sonia A. De Leo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
HEAT SHOCK PROTEINS Cancer Research CIENCIAS MÉDICAS Y DE LA SALUD biology Bioquímica y Biología Molecular Hsp90 CANCER 03 medical and health sciences Medicina Básica 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis TPR-PROTEIN Cancer research biology.protein Molecular Medicine IMMUNOPHILINS Cancer biology |
| Popis: | The identification of new factors that may function as cancer markers and becomeeventual pharmacologic targets is a challenge that may influence the management of tumor developmentand management. Recent discoveries connecting Hsp90-binding immunophilins with theregulation of signalling events that can modulate cancer progression transform this family of proteinsin potential unconventional factors that may impact on the screening and diagnosis of malignantdiseases. Immunophilins are molecular chaperones that group a family of intracellular receptorsfor immunosuppressive compounds. A subfamily of the immunophilin family is characterizedby showing structural tetratricopeptide repeats, protein domains that are able to interact with theC-terminal end of the molecular chaperone Hsp90, and via the proper Hsp90-immunophilin complex,the biological properties of a number of client-proteins involved in cancer biology are modulated.Recent discoveries have demonstrated that two of the most studied members of this Hsp90-binding subfamily of immunophilins, FKBP51 and FKBP52, participate in several cellular processessuch as apoptosis, carcinogenesis progression, and chemoresistance. While the expressionlevels of some members of the immunophilin family are affected in both cancer cell lines andhuman cancer tissues compared to normal samples, novel regulatory mechanisms have emergedduring the last few years for several client-factors of immunophilins that are major players in cancerdevelopment and progression, among them steroid receptors, the transctiption factor NF-κBand the catalytic subunit of telomerase, hTERT. In this review, recent findings related to the biologicalproperties of both iconic Hsp90-binding immunophilins, FKBP51 and FKBP52, are reviewedwithin the context of their interactions with those chaperoned client-factors. The potentialroles of both immunophilins as potential cancer biomarkers and non-conventional pharmacologictargets for cancer treatment are discussed.Keywords: Heat-shock proteins; immunophilins; cancer; peptidylprolyl isomerase; Fil: de Leo, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Zgajnar, Nadia Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Mazaira, Gisela Ileana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Erlejman, Alejandra Giselle. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Galigniana, Mario Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina |
| Databáze: | OpenAIRE |
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