Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

Autor: David Yannick Leger, Frédérique Brégier, Vincent Sol, Vincent Lequart, Robert Granet, Bertrand Liagre, Chloë Fidanzi-Dugas, Vincent Chaleix, Gautier Mark Arthur Ndong Ntoutoume, Nicolas Joly, Jean-Pierre Mbakidi
Přispěvatelé: Laboratoire de Chimie des Substances Naturelles (LCSN), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Université d'Artois (UA)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Curcumin
Cancer cells
Clinical Biochemistry
Pharmaceutical Science
Beta-Cyclodextrins
02 engineering and technology
010402 general chemistry
01 natural sciences
Biochemistry
chemistry.chemical_compound
Cell Line
Tumor
Drug Discovery
Humans
Organic chemistry
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Cellulose
Molecular Biology
Cell Proliferation
chemistry.chemical_classification
Drug Carriers
Microscopy
Confocal
Cyclodextrin
Chemistry
[CHIM.ORGA]Chemical Sciences/Organic chemistry
beta-Cyclodextrins
Organic Chemistry
Cellulose nanocrystals
technology
industry
and agriculture
Cationic polymerization
021001 nanoscience & nanotechnology
Combinatorial chemistry
In vitro
0104 chemical sciences
3. Good health
Drug delivery
Molecular Medicine
Nanoparticles
0210 nano-technology
Drug carrier
HT29 Cells
Zdroj: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, 26, pp.941-945. ⟨10.1016/j.bmcl.2015.12.060⟩
ISSN: 0960-894X
Popis: International audience; The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC50s lower than that of curcumin alone.
Databáze: OpenAIRE
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