Gene therapy in pancreatic cancer
| Autor: | Zhong-Sheng Xia, Si-Xue Liu, Ying-Qiang Zhong |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
medicine.medical_specialty Tumor suppressor gene Genetic enhancement Apoptosis Gene delivery Viral vector Internal medicine medicine Animals Humans Gene Silencing Topic Highlight Cell Proliferation Neovascularization Pathologic business.industry Gastroenterology Gene Transfer Techniques Cancer General Medicine Genetic Therapy Oncogenes Suicide gene medicine.disease Clinical trial Pancreatic Neoplasms Treatment Outcome Drug Resistance Neoplasm Cancer research business Chemoradiotherapy Signal Transduction |
| Zdroj: | World journal of gastroenterology. 20(37) |
| ISSN: | 2219-2840 |
| Popis: | Pancreatic cancer (PC) is a highly lethal disease and notoriously difficult to treat. Only a small proportion of PC patients are eligible for surgical resection, whilst conventional chemoradiotherapy only has a modest effect with substantial toxicity. Gene therapy has become a new widely investigated therapeutic approach for PC. This article reviews the basic rationale, gene delivery methods, therapeutic targets and developments of laboratory research and clinical trials in gene therapy of PC by searching the literature published in English using the PubMed database and analyzing clinical trials registered on the Gene Therapy Clinical Trials Worldwide website (http://www. wiley.co.uk/genmed/ clinical). Viral vectors are main gene delivery tools in gene therapy of cancer, and especially, oncolytic virus shows brighter prospect due to its tumor-targeting property. Efficient therapeutic targets for gene therapy include tumor suppressor gene p53, mutant oncogene K-ras, anti-angiogenesis gene VEGFR, suicide gene HSK-TK, cytosine deaminase and cytochrome p450, multiple cytokine genes and so on. Combining different targets or combination strategies with traditional chemoradiotherapy may be a more effective approach to improve the efficacy of cancer gene therapy. Cancer gene therapy is not yet applied in clinical practice, but basic and clinical studies have demonstrated its safety and clinical benefits. Gene therapy will be a new and promising field for the treatment of PC. |
| Databáze: | OpenAIRE |
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