Fluoroquinolone Antibiotics in a Hospital Sewage Line; Occurrence, Distribution and Impact on Bacterial Resistance

Autor:	Per-Åke Jarnheimer, Jakob Ottoson, Richard Lindberg, Thor-Axel Stenström, Magnus Johansson, Mats Tysklind, Mari-Mall Winner, Björn Olsen
Rok vydání:	2004
Předmět:	Sweden Microbiology (medical) Sewage General Immunology and Microbiology General Medicine Gram-Positive Bacteria Medical Waste Risk Assessment Hospitals Infectious Diseases Drug Resistance Bacterial Gram-Negative Bacteria Humans Longitudinal Studies Medical Waste Disposal Fluoroquinolones
Zdroj:	Scandinavian Journal of Infectious Diseases. 36:752-755
ISSN:	1651-1980 0036-5548
DOI:	10.1080/00365540410021027a
Popis:	In hospital sewage lines, human faecal bacteria are exposed to antibiotics, posing a risk for selection of antibiotic resistant microorganisms. We constructed a system for continuous sampling in a hospital sewage line that allowed us to study longitudinal establishment of bacteria, concentrations of antibiotics, and selection of bacterial resistance in waste water, sediment and biofilm. The focus in this study was on fluoroquinolones, a widely used group of antibiotics with increasing resistance problems. We found low levels of ciprofloxacin and ofloxacin in waste water but high concentrations in sediment. Despite the high levels of fluoroquinolones bound to sediment, we did not find any development of resistance against fluoroquinolones in Enterobacteriacae spp. and faecal enterococci isolated from sediment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3f0f0ace860bf982625677e93c2a93 https://doi.org/10.1080/00365540410021027a Zobrazit plný text záznamu Plný text ve formátu PDF