The calcium endocrine system of adolescent rhesus monkeys and controls before and after spaceflight
| Autor: | Meena Navidi, Sara B. Arnaud, Myrtle Thierry-Palmer, Rita Dotsenko, Leonard J. Deftos, Richard E. Grindeland, A. J. Bigbee |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Calcitonin
Aging medicine.medical_specialty Hydrocortisone Physiology Endocrinology Diabetes and Metabolism Parathyroid hormone chemistry.chemical_element Calcium Biology Spaceflight Intestinal absorption law.invention Eating Calcitriol law Endocrine Glands Physiology (medical) Internal medicine medicine Animals Homeostasis Calcium metabolism Phosphorus Space Flight Alkaline Phosphatase Macaca mulatta Diet Endocrinology medicine.anatomical_structure Intestinal Absorption chemistry Parathyroid Hormone Creatinine Parathyroid gland Endocrine gland |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 282:E514-E521 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.00299.2001 |
| Popis: | The calcium endocrine system of nonhuman primates can be influenced by chairing for safety and the weightless environment of spaceflight. The serum of two rhesus monkeys flown on the Bion 11 mission was assayed pre- and postflight for vitamin D metabolites, parathyroid hormone, calcitonin, parameters of calcium homeostasis, cortisol, and indexes of renal function. Results were compared with the same measures from five monkeys before and after chairing for a flight simulation study. Concentrations of 1,25-dihydroxyvitamin D were 72% lower after the flight than before, and more than after chairing on the ground (57%, P < 0.05). Decreases in parathyroid hormone did not reach significance. Calcitonin showed modest decreases postflight ( P < 0.02). Overall, effects of spaceflight on the calcium endocrine system were similar to the effects of chairing on the ground, but were more pronounced. Reduced intestinal calcium absorption, losses in body weight, increases in cortisol, and higher postflight blood urea nitrogen were the changes in flight monkeys that distinguished them from the flight simulation study animals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|