Real-world evaluation of the impact of radiotherapy and chemotherapy in elderly patients with glioblastoma based on age and performance status
| Autor: | Samantha M. Buszek, Neil Chevli, Hesham Elhalawani, Karine A. Al Feghali, Caroline Chung, Pamela K. Allen |
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| Rok vydání: | 2020 |
| Předmět: |
Chemotherapy
medicine.medical_specialty Performance status Proportional hazards model business.industry medicine.medical_treatment Medicine (miscellaneous) Cancer Retrospective cohort study Combination chemotherapy Original Articles medicine.disease Chemotherapy regimen Radiation therapy Internal medicine medicine business |
| Zdroj: | Neurooncol Pract |
| ISSN: | 2054-2585 2054-2577 |
| DOI: | 10.1093/nop/npaa064 |
| Popis: | Background This retrospective study investigated the impact of, in addition to age, the management and outcomes of elderly patients with glioblastoma (GBM). Methods The National Cancer Database was queried between 2004 and 2015 for GBM patients age 60 years and older. Three age groups were created: 60 to 69, 70 to 79, and 80 years and older, and 4 age/KPS groups: “age ≥ 60/ KPS Results A total of 48 540 patients with a median age of 70 years (range, 60-90 years) at diagnosis, and a median follow-up of 6.8 months (range, 0-151 months) were included. Median survival was 5.0, 15.2, 9.6, and 6.8 months in groups 1, 2, 3, and 4, respectively (P Conclusions In elderly patients with newly diagnosed GBM, those with good KPS fared best with combined ChT and RT across all age groups. Performance status is a key prognostic factor that should be considered for management decisions in these patients. |
| Databáze: | OpenAIRE |
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