Polymorphism of Progesterone: Relative Stabilities of the Orthorhombic Phases I and II Inferred from Topological and Experimental Pressure-Temperature Phase Diagrams
| Autor: | Marc-Antoine Perrin, Nestor Veglio, René Céolin, Josep-Lluis Tamarit, Philippe Espeau, Maria Barrio |
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| Rok vydání: | 2009 |
| Předmět: |
Differential Thermal Analysis
Calorimetry Differential Scanning Triple point Chemistry Temperature Pharmaceutical Science Thermodynamics Computer Science::Computational Geometry Topology Differential scanning calorimetry Drug Stability X-Ray Diffraction Clausius–Clapeyron relation Lattice (order) Differential thermal analysis Microscopy Electron Scanning Pressure Orthorhombic crystal system Crystallization Thermal analysis Algorithms Progesterone Phase diagram |
| Zdroj: | Journal of Pharmaceutical Sciences. 98:1657-1670 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.21541 |
| Popis: | Temperatures and melting enthalpies of orthorhombic Phases I and II of natural progesterone, together with the temperature dependence of their lattice parameters and the specific volume of the melt at ordinary pressure, have been determined. With these results, a topological pressure-temperature ( P-T ) phase diagram accounting for the thermodynamic relationships between these phases has been constructed by way of the Clapeyron equation. The dependence of the melting temperature on the pressure has also been determined for each phase by high-pressure differential thermal analysis. It was found that, upon increasing the pressure, the melting curves converge to the I–II-liquid triple point ( T I–II-liquid = 459.4 K, P I–II-liquid = 149.0 MPa), in close agreement with its topological location. This entails that Phase II should exhibit a stable phase region at higher pressure. |
| Databáze: | OpenAIRE |
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