A 'green' synthesis of N-(quinoline-3-ylmethylene)benzohydrazide derivatives and their cytotoxicity activities

Autor:	Lingam Venkata Reddy, Suresh Babu Nallapati, Syed Sultan Beevi, Lakshmi Narasu Mangamoori, Khagga Mukkanti, Sarbani Pal
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	PEG 400 chemistry.chemical_compound Chemistry Stereochemistry Quinoline cytotoxicity General Chemistry macromolecular substances Cytotoxicity 2-chloroquinoline-3-carboxaldehyde Medicinal chemistry acylhydrazone
Zdroj:	Journal of the Brazilian Chemical Society v.22 n.9 2011 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ Journal of the Brazilian Chemical Society, Volume: 22, Issue: 9, Pages: 1742-1749, Published: SEP 2011
Popis:	Relatamos algumas moleculas hibridas baseadas na N-(quinolina-3-ilmetileno)benzoidrazida, cuja sintese foi realizada usando-se 2-cloroquinolina-3-carbaldeido e uma variedade de hidrazidas substituidas, em PEG 400. O solvente PEG 400 foi recuperado e reutilizado diversas vezes na presente reacao, mostrando-se eficiente em termos de rendimento dos produtos. Alguns dos compostos sintetizados mostraram atividade citotoxica significativa quando testados in vitro. We report some hybrid molecules based on N-(quinoline-3-ylmethylene)benzohydrazide template the synthesis of which was carried out using 2-chloroquinoline-3-carbaldehyde and a variety of substituted hydrazides in PEG 400. The “green” solvent PEG 400 was recovered and reused for several times in the present reaction and was found to be effective in terms of product yield. Some of the compounds synthesized showed significant cytotoxic activity when tested in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad32b41d8378d5ebfc716f18243222cc http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000900017 Zobrazit plný text záznamu