Identification of self peptides bound to purified HLA-B27
| Autor: | D. R. Madden, Theodore S. Jardetzky, R. A. Robinson, William S. Lane, Don C. Wiley |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
chemistry.chemical_classification
Multidisciplinary Protein family Molecular Sequence Data Peptide Plasma protein binding Biology Molecular biology Biochemistry chemistry Ribosomal protein Sequence Homology Nucleic Acid Animals Humans Amino Acid Sequence Nuclear protein Binding site Peptides Peptide sequence Chromatography High Pressure Liquid HLA-B27 Antigen Binding selectivity Protein Binding |
| Zdroj: | Nature. 353:326-329 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/353326a0 |
| Popis: | A pool of endogenous peptides bound to the human class I MHC molecule, HLA-B27, has been isolated. Microsequence analysis of the pool and of 11 HPLC-purified peptides provides information on the binding specificity of the HLA-B27 molecule. The peptides all seem to be nonamers, seven of which match to protein sequences in a database search. These self peptides derive from abundant cytosolic or nuclear proteins, such as histone, ribosomal proteins, and members of the 90K heat-shock protein family. |
| Databáze: | OpenAIRE |
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