Epidemiology of non-Hodgkin lymphomas in Tyrol/Austria from 1991 to 2000
| Autor: | H Mühlböck, Alexandar Tzankov, Stefan Dirnhofer, Willi Oberaigner, T Mitterlechner, Michael Fiegl |
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| Rok vydání: | 2006 |
| Předmět: |
Oncology
Adult Male Pathology medicine.medical_specialty Adolescent Population Age adjustment Follicular lymphoma Pathology and Forensic Medicine Age Distribution immune system diseases hemic and lymphatic diseases Internal medicine medicine Humans Sex Distribution education Child Aged education.field_of_study business.industry Incidence (epidemiology) Lymphoma Non-Hodgkin Infant Newborn Infant General Medicine Middle Aged medicine.disease Lymphoma Log-rank test Austria Child Preschool Mantle cell lymphoma Female Original Article business Epidemiologic Methods Diffuse large B-cell lymphoma |
| Zdroj: | Journal of clinical pathology. 59(1) |
| ISSN: | 0021-9746 |
| Popis: | Aims: To analyse the entity specific incidence and disease specific survival (DSS) of non-Hodgkin lymphomas (NHLs) in Tyrol/Austria, 1991–2000. Methods: Data from 1307 NHLs (excluding primary cutaneous lymphomas and monoclonal gammopathies of undetermined significance) were obtained. Current status was available for all patients. Except for 29 cases of small lymphocytic (CLL/SLL), lymphoblastic leukaemia (ALL), and myeloma (MM), which were diagnosed cytologically, diagnoses were reclassified on paraffin wax embedded archival material according to new World Health Organisation criteria. Sex specific age adjusted standardised incidence rates were computed using Segi’s population weighting. Annual incidence changes were calculated by weighted least square regression analysis. Survival was estimated by the Kaplan–Meier method and compared by log rank test. Results: NHL more frequently affected men (male/female ratio, 1.52). Mean age of occurrence was 61 and 66 years for men and women, respectively. The incidence rate of 14.3 remained constant. There was a significant increase in diffuse large B cell lymphoma (DLBCL) and decrease in CLL/SLL in men, and a decrease in MM in women. Overall DSS was 64% during the mean follow up (43 months). Age, T-NHL, λ light chain restriction in MM, and male sex in CLL/SLL were associated with poor prognosis. In B-NHL, DSS decreased in the following order: hairy cell leukaemia, marginal zone lymphoma, follicular lymphoma, Burkitt lymphoma, ALL, DLBCL, CLL, MM, and mantle cell lymphoma. Conclusions: The incidence of NHL in Tyrol has changed in the past decade, with a significant increase in DLBCL, decrease in CLL/SLL in men, and decrease in MM in women. |
| Databáze: | OpenAIRE |
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