Promotion of metastases by tumor necrosis factor in rats bearing Dunning R3327 MAT-LyLu prostatic cancer
| Autor: | Gen-Ichiro Soma, Tatsuo Iizumi, Takashi Umeda, Tsunetada Yazaki |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Lung Neoplasms Urology medicine.medical_treatment Indomethacin Adenocarcinoma Dinoprostone Metastasis Internal medicine medicine Tumor Cells Cultured Animals Humans Prostaglandin E2 Neoplasm Metastasis business.industry Tumor Necrosis Factor-alpha Lethal dose Cancer Prostatic Neoplasms Immunotherapy medicine.disease Recombinant Proteins Rats Cytokine Endocrinology Cancer research Tumor necrosis factor alpha business medicine.drug |
| Zdroj: | Urologia internationalis. 51(2) |
| ISSN: | 0042-1138 |
| Popis: | We examined the effects of recombinant human tumor necrosis factor (rTNF) on highly metastatic rat prostatic cancer, Dunning R3327 MAT-LyLu, in vivo. It seemed that the inhibition of tumor growth needed more than 5 x 10(5) units of rTNF and this dose was near the lethal dose. Concerning the effect of rTNF on metastasis, we found that the metastasis to lung was promoted by 1 x 10(5) units of rTNF and the promotion of metastasis was restricted by indomethacin. Although MAT-LyLu cells were producing a significant amount of prostaglandin E2, rTNF did not enhance the production. We therefore consider that the promotion of metastasis was not mediated by prostaglandin E2 from MAT-LyLu cells but was mediated by other very complicated conditions. Further studies are necessary to resolve the mechanisms. |
| Databáze: | OpenAIRE |
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