COVID-19: immunopathogenesis and Immunotherapeutics
| Autor: | Bo Huang, Xiaochun Wan, Jinyan Liu, Li Yang, Shasha Liu, Youhai H. Chen, Zhixin Zhang, Yi Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment Pneumonia Viral lcsh:Medicine Review Article Disease Systemic inflammation Disease Outbreaks Betacoronavirus 03 medical and health sciences 0302 clinical medicine Immune system Immunity Immunopathology medicine Genetics Humans Pandemics lcsh:QH301-705.5 SARS-CoV-2 Septic shock business.industry Organ dysfunction lcsh:R COVID-19 Immunotherapy biochemical phenomena metabolism and nutrition medicine.disease Shock Septic Immunity Innate 030104 developmental biology lcsh:Biology (General) 030220 oncology & carcinogenesis Immunology Infectious diseases Cytokines medicine.symptom Coronavirus Infections business |
| Zdroj: | Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-8 (2020) Signal Transduction and Targeted Therapy |
| ISSN: | 2059-3635 |
| Popis: | The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected patients worldwide. The host immune response to SARS-CoV-2 appears to play a critical role in disease pathogenesis and clinical manifestations. SARS-CoV-2 not only activates antiviral immune responses, but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19, leading to lymphopenia, lymphocyte dysfunction, and granulocyte and monocyte abnormalities. These SARS-CoV-2-induced immune abnormalities may lead to infections by microorganisms, septic shock, and severe multiple organ dysfunction. Therefore, mechanisms underlying immune abnormalities in patients with COVID-19 must be elucidated to guide clinical management of the disease. Moreover, rational management of the immune responses to SARS-CoV-2, which includes enhancing anti-viral immunity while inhibiting systemic inflammation, may be key to successful treatment. In this review, we discuss the immunopathology of COVID-19, its potential mechanisms, and clinical implications to aid the development of new therapeutic strategies against COVID-19. |
| Databáze: | OpenAIRE |
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