Erectile dysfunction in compensated liver cirrhosis
| Autor: | Roberto Filomia, Giovanni Oliva, Francesca Saffioti, Gaia Caccamo, Antonino Di Benedetto, Concetta Pitrone, Giovanni Squadrito, Irene Cacciola, Carlo Saitta, Giovanni Raimondo, Angela Alibrandi, Sergio Maimone |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis Cirrhosis Depression scale Adrenergic beta-Antagonists Population Child Pugh A Compensated chronic liver disease Erectile dysfunction Liver cirrhosis Sexual disturbance Hepatology Gastroenterology Disease Severity of Illness Index Diabetes Complications 03 medical and health sciences 0302 clinical medicine Risk Factors Surveys and Questionnaires Diabetes mellitus Internal medicine Hypertension Portal Prevalence Humans Medicine Prospective Studies Risk factor education Aged education.field_of_study business.industry Middle Aged medicine.disease Logistic Models Italy 030220 oncology & carcinogenesis Multivariate Analysis 030211 gastroenterology & hepatology business |
| Popis: | Background Data on erectile dysfunction (ED) in cirrhotic patients are limited as yet. Aim of this study was to investigate the prevalence of ED and the factors potentially involved in its development in compensated cirrhosis. Methods We prospectively enrolled 102 male (mean age 63 ± 10 years) affected by cirrhosis in Child–Pugh Class A. The following questionnaires were used: simplified International Index of Erectile Function (IIEF-5) Questionnaire, Centre of Epidemiologic Studies Depression Scale and ANDROTEST. Results ED was found in 57/102(55.9%) patients, and was mild, moderate and severe in 21(36.8%), 6(10.5%) and 30(52.6%) subjects, respectively. ED patients were significantly older than those without (66 ± 10 vs 60 ± 10,p = 0.006); ED prevalence gradually increased with age. There was no statistically significant difference between patients with and without ED concerning the coexistence of diabetes, hypertension, and cardiovascular disease. Age(p = 0.040) and serum haemoglobin(p = 0.027) were identified as predictors of ED on multivariate analysis. Liver-related factors and pharmacological treatment, including β-blockers, were not associated with the presence of ED. Conclusions In patients with compensated liver cirrhosis, even in concomitance with other chronic comorbidities, the prevalence of ED is not markedly different from the general population. Compensated cirrhosis per se is not a risk factor for ED occurrence. Older age and low haemoglobin values are significantly associated with ED in cirrhotics. |
| Databáze: | OpenAIRE |
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