Rhein-PEG-nHA conjugate as a bone targeted drug delivery vehicle for enhanced cancer chemoradiotherapy
| Autor: | Jingou Ji, Jia Song, Bochu Wang, Xiaoliang Chen, Rui Qing, Dongliang Zhai, Shilei Hao, Xiuying Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Immunoconjugates
Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering Anthraquinones Bone Neoplasms Breast Neoplasms macromolecular substances 02 engineering and technology Polyethylene Glycols 03 medical and health sciences Mice Breast cancer Drug Delivery Systems In vivo Cell Line Tumor PEG ratio medicine Animals Humans General Materials Science Doxorubicin Neoplasm Metastasis 030304 developmental biology 0303 health sciences Chemistry technology industry and agriculture Cancer 021001 nanoscience & nanotechnology medicine.disease Xenograft Model Antitumor Assays Durapatite Targeted drug delivery Cancer research Molecular Medicine Female 0210 nano-technology Phosphorus Radioisotopes Chemoradiotherapy medicine.drug Conjugate |
| Zdroj: | Nanomedicine : nanotechnology, biology, and medicine. 27 |
| ISSN: | 1549-9642 |
| Popis: | Bone-targeted therapies have been the choice of treatments for cancer metastases in bone to minimize skeletal morbidity and preserve patients' quality of life. Rhein is of particular interest due to its high bone affinity. Here we reported a novel Rhein- polyethylene glycol (PEG)-nano hydroxyapatite (nHA) conjugate to deliver doxorubicin (DOX) and Phosphorus-32 (32P) simultaneously for enhanced cancer chemo-radiotherapy. The synthetic Rhein-PEG-nHA conjugates were sphere in shape with an average diameter of ~120 nm. Their morphology, drug release and bone affinity were confirmed in vitro. The release profiles of DOX depend on pH condition, but 32P exhibited good stability. Rhein-PEG-nHA also showed high bone affinity in vivo, and the tumor volume decreased after the DOX@Rhein-PEG-nHA and 32P@Rhein-PEG-nHA treatments. Most importantly, the DOX/32P@Rhein-PEG-nHA showed the strongest inhibition on the growth of bone metastases of breast cancer. We revealed the potential of Rhein-PEG-nHA in combined chemo-radiation treatment for bone metastases of breast cancer. |
| Databáze: | OpenAIRE |
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