Templated synthesis of spherical RNA nanoparticles with gene silencing activity
| Autor: | Hanadi F. Sleiman, Michael D. Dore, Aurélie Lacroix, Johans J. Fakhoury |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Nanoparticle
02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis Component (UML) Materials Chemistry Humans Gene silencing Gene Silencing Aqueous solution Molecular Structure Chemistry Metals and Alloys RNA General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Template Ceramics and Composites Biophysics Nanoparticles 0210 nano-technology HeLa Cells |
| Zdroj: | Chemical Communications. 54:11296-11299 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c8cc06994h |
| Popis: | RNA has inherent therapeutic and structural properties that make it an important component of biologically-functional nanoparticles. Using DNA-amphiphiles as synthetic templates, we report the synthesis of two classes of RNA-amphiphiles that self-assemble into spherical nanoparticles in aqueous solution and show gene silencing activity. |
| Databáze: | OpenAIRE |
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