Prevalence of renal lesions in patients with type 1 and 2 diabetes mellitus in the Russian Federation
| Autor: | Igor Vladislavovich Kazakov, Sergey Andreevich Martynov, Natalya Petrovna Trubitsyna, Olga Yur'evna Sukhareva, Oksana Vladimirovna Maslova, Yury Ivanovich Suntsov, Marina Vladimirovna Shestakova, Olga K. Vikulova |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty chronic renal disease RC620-627 microalbuminuria Endocrinology Diabetes and Metabolism medicine.medical_treatment Renal function urologic and male genital diseases Gastroenterology chemistry.chemical_compound Endocrinology Internal medicine Diabetes mellitus Internal Medicine Medicine type 1 and 2 diabetes mellitus Nutritional diseases. Deficiency diseases Glycemic Creatinine glomerular filtration rate Proteinuria business.industry Insulin Albumin medicine.disease chemistry Microalbuminuria medicine.symptom proteinuria business |
| Zdroj: | Сахарный диабет, Vol 12, Iss 4, Pp 47-51 (2009) |
| ISSN: | 2072-0378 2072-0351 |
| Popis: | Aim. To study the prevalence of renal lesions in adult patients with type 1 and 2 diabetes mellitus in the Russian Federation. Materials and methods. A total of 7174 patients with DM1 and DM2 were examined in 20 regions of the Russian Federation for blood HbA 1c creatinine,urea, and cholesterol levels, albumin excretion in a single urine sample, AP, and eye fundus condition. Albumin concentration from 20 to 200mg/l was regarded as microalbuminuria (MAU) that above 200 mg/l as proteinuria (PU). The glomerular filtration rate (GFR) was calculated fromCockroft-Gault formula. Statistica-6 program was used for statistical treatment of the results of the study. They are represented as median, 25th and75th percentile values (Me [25%;75%]). Differences between all parameters is considered significant at p Results. Pathologic albumin excretion was documented in 42,1 and 45,3% of the DM1 and DM2 patients. Its prevalence increased with age andDM duration as well as at poor AP and glycemic control. Stage 2 chronic renal disease developed in 16,5 and 23,7%, stage 3 in 4,2 and 6,3%,stage 4-5 in 0,9 and 0,2% of the DM1 and DM2 patients respectively. 15,0 and 41,2% of DM1 and DM2 patients with MAU needed additionalexamination to elucidate non-diabetic origin of CRD. 40% of the DM2 patients with impaired GFR and poor glycemic control had to be transferredto insulin therapy. |
| Databáze: | OpenAIRE |
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