Neuropathology of Heart Transplantation
| Autor: | John C. E. Kaufmann, L.C. Ang, J.M. Gillett |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent medicine.medical_treatment Ischemia Neuropathology Aspergillosis Brain Ischemia Sepsis Postoperative Complications Seizures medicine Humans Cerebral Hemorrhage Intracerebral hemorrhage Heart transplantation Brain Diseases business.industry Cerebral Infarction General Medicine Middle Aged medicine.disease Transplantation Mycoses Neurology Cytomegalovirus Infections Heart Transplantation Female Neurology (clinical) Complication business |
| Zdroj: | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 16:291-298 |
| ISSN: | 2057-0155 0317-1671 |
| Popis: | The neuropathology of 18 cardiac transplant recipients was reviewed with the clinical findings. Pathological changes were noted in the central nervous system (CNS) in 94% of the patients, the most frequent being cerebral vascular in origin (72%). Eight patients (44%) had multiple cerebral infarcts and morphologically, a large number of these antedated the transplantation. In addition 4 patients had acute focal ischemic changes which occurred after transplantation. Intracranial hemorrhage was noted in 5 patients (28%), including one case of fatal intracerebral hemorrhage following an acute hypertensive episode after the transplantation. While systemic infection was common (10 patients), there were only 5 cases of intracranial infection; including 3 cases of cytomegalovirus infection, one of candidiasis and one of aspergillosis. Post-transplant seizures, occurring in a third of the patients, were related to a variety of causative factors such as sepsis, intracranial hemorrhage, cerebral ischemia, metabolic encephalopathy and cyclosporin neurotoxicity. Of note in this series was the absence of CNS lymphoma or other systemic lymphoproliferative disorder. |
| Databáze: | OpenAIRE |
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