Preparation and characterization of electrospun alginate nanofibers loaded with ciprofloxacin hydrochloride
| Autor: | Ivan Moreno, Silvia Irusta, Justyna Michna, Enrique Gamez, Agnieszka Kyzioł |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Materials science Polymers and Plastics Ethylene oxide Scanning electron microscope Organic Chemistry General Physics and Astronomy 02 engineering and technology Polymer Poloxamer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Electrospinning 0104 chemical sciences chemistry.chemical_compound Chemical engineering Pulmonary surfactant chemistry Nanofiber Materials Chemistry Composite material 0210 nano-technology Ciprofloxacin Hydrochloride |
| Zdroj: | Zaguán. Repositorio Digital de la Universidad de Zaragoza instname |
| Popis: | Alginate nanofibers were prepared in the presence of poly(ethylene oxide) (PEO), a surfactant Pluronic F-127, and a model drug (ciprofloxacin hydrochloride, CpHCl), all mixed prior to electrospinning. It was demonstrated that addition of a carrier polymer (PEO) and a small amount of surfactant are necessary to obtain uniform alginate fibers with cylindrical shape and regular morphology. Importantly, PEO was completely removed from the resulting nanofibers during cross-linking and stabilization post-treatment. The stable alginate fibers loaded with CpHCl were examined by scanning electron microscopy and the average diameter of the fibers ranged from 109 nm (unloaded fibers) to 161 nm (loaded fibers). The release of a studied antibiotic from the nanofibers, characterized by a final loading efficiency of 51%, was tested in physiological conditions. It was revealed that ca. 24% of CpHCl is released during first 20 h with combined transport mechanism, however with the predominant contribution of Fickian diffusion. |
| Databáze: | OpenAIRE |
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