The composition and end-group functionality of sterically stabilized nanoparticles enhances the effectiveness of co-administered cytotoxins

Autor:	Eh Hau Pan, Brian S. Hawkett, Renee Whan, Nicole S. Bryce, Nicole W. S. Fong, Binh T. T. Pham, Trevor W. Hambley, Nirmesh Jain
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Steric effects Biomedical Engineering Cationic polymerization Iron oxide Nanoparticle Polymer Combinatorial chemistry End-group chemistry.chemical_compound chemistry Drug delivery Organic chemistry General Materials Science Cytotoxicity
Zdroj:	Biomater. Sci.. 1:1260-1272
ISSN:	2047-4849 2047-4830
Popis:	Diffusion of active cytotoxic agents throughout an entire solid tumour is a particular challenge to successful drug delivery. Here we show the simple and robust generation of non-toxic, 10-15 nm superparamagnetic iron oxide nanoparticles (SPIONs) that have been sterically stabilized by either 100% anionic or 100% cationic or 100% neutral end-functionalized steric stabilizers or by novel combinations of cationic and neutral end-functionalized polymer. When these nanoparticles were co-administered with various anti-cancer drugs, a significant increase in the diffusion and effectiveness of the cytotoxin in a 3-dimensional model of a solid tumour was shown for specific combinations of surface functionality and cytotoxin. The critical determinant of enhanced cytotoxin diffusion and effectiveness was the end functionality of the steric stabilizers and not the core composition (either iron oxide, silica or gold). We provide evidence that SPIONs stabilized with heterogeneous steric stabilizers enhance nuclear uptake of doxorubicin across multiple cell layers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad277ee30bdc2a1af51d64c02f549b7e https://doi.org/10.1039/c3bm60120j Zobrazit plný text záznamu