Clinical evaluation of total and lipid bound sialic acid levels in oral precancer and oral cancer
| Autor: | Syed Ahmed Taqi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
spectrophotometer Response to therapy Gastroenterology oral precancer Malignant transformation chemistry.chemical_compound Internal medicine medicine Katopodis In patient business.industry Cancer oral cancer medicine.disease Sialic acid periodate-thiobarbituric acid Oncology chemistry sialic acid Healthy individuals Pediatrics Perinatology and Child Health Immunology Original Article business Clinical evaluation |
| Zdroj: | Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology |
| ISSN: | 0975-2129 0971-5851 |
| DOI: | 10.4103/0971-5851.96967 |
| Popis: | Aims: Special attention has been given to define the biochemical changes in cell-surface glycoproteins and glycolipids that take place during malignant transformation. This study was thus designed to explore the clinical utility of total and lipid bound sialic acid (LSA) in patients with oral precancer and oral cancer. Materials and Methods: Blood samples were obtained from 95 subjects divided into three groups, namely healthy individuals, oral cancer, and precancer. Serum total and LSA levels were determined using periodate-thiobarbituric acid method and Katopodis et al. method, respectively. Finally, spectrophotometricreadings were obtained. Results: Mean values of serum sialic acid (total and lipid bound) in oral cancer were significantly higher than control and the precancer group (P |
| Databáze: | OpenAIRE |
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