Strategies for prevention of neonatal chronic lung disease
| Autor: | Cynthia H. Cole, John M. Fiascone |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Lung Diseases
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Anti-Inflammatory Agents Psychological intervention Obstetric Labor Premature Pregnancy medicine Humans Intensive care medicine Glucocorticoids Thyrotropin-Releasing Hormone business.industry Infant Newborn Obstetrics and Gynecology Gestational age Vitamins respiratory system Respiration Artificial respiratory tract diseases Lung disease Chronic Disease Pediatrics Perinatology and Child Health Female business Infant Premature |
| Zdroj: | Seminars in Perinatology. 24:445-462 |
| ISSN: | 0146-0005 |
| DOI: | 10.1053/sper.2000.20083 |
| Popis: | Chronic lung disease (CLD) of prematurity remains a substantial problem despite modern perinatal and neonatal care. CLD remains related to gestational age and lung immaturity, although it has become clear that severe initial lung disease is not a prerequisite for CLD to develop. Attempts to prevent CLD to date have not adequately addressed the multifactorial nature of the complex pathophysiology that leads to CLD. Thus, results have been modest at best. Prevention of CLD will require a multifaceted approach with specific interventions and care practices focused on different aspects of the pathway that leads to CLD. This review considers new information related to causation of CLD and the magnitude of the effect of prevention strategies tested to date. This article also advances the hypothesis that CLD is preventable with a global strategy of minimizing inciting events, optimizing management, and specific therapies aimed at intrinsic vulnerabilities. |
| Databáze: | OpenAIRE |
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