Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E
| Autor: | Stephen Baker, Giordano Rampioni, Paul Williams, David M. Bulmer, Joe Gray, C. M. Anjam Khan, Derek Pickard, Klaus Winzer, Michail H. Karavolos, Gordon Dougan, Ira Schmalen, Hannah Spencer, Alasdair Ivens, Maria Fookes |
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| Přispěvatelé: | Karavolos, Michail H, Bulmer, David M, Spencer, Hannah, Rampioni, Giordano, Schmalen, Ira, Baker, Stephen, Pickard, Derek, Gray, Joe, Fookes, Maria, Winzer, Klau, Ivens, Alasdair, Dougan, Gordon, Williams, Paul, Khan, Anjam CM |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Salmonella
Epinephrine Down-Regulation Biology medicine.disease_cause Salmonella typhi Hemolysis complex mixtures Biochemistry Microbiology Hemolysin Proteins Norepinephrine Bacterial Proteins Downregulation and upregulation Stress Physiological Genetics medicine Hormone metabolism Molecular Biology Salmonella Hormones Haemolysin MicA Cpx Scientific Reports Hemolysin Gene Expression Regulation Bacterial bacterial infections and mycoses Haemolysis Propranolol Hormones bacteria Bacterial outer membrane Protein Kinases Bacterial Outer Membrane Proteins Signal Transduction Hormone |
| Popis: | Salmonella enterica serovar Typhi (S. typhi) causes typhoid fever. We show that exposure of S. typhi to neuroendocrine stress hormones results in haemolysis, which is associated with the release of haemolysin E in membrane vesicles. This effect is attributed to increased expression of the small RNA micA and RNA chaperone Hfq, with concomitant downregulation of outer membrane protein A. Deletion of micA or the two-component signal-transduction system, CpxAR, abolishes the phenotype. The hormone response is inhibited by the β 2-blocker propranolol. We provide mechanistic insights into the basis of neuroendocrine hormone-mediated haemolysis by S. typhi, increasing our understanding of inter-kingdom signalling. © 2011 European Molecular Biology Organization Embo. |
| Databáze: | OpenAIRE |
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